protein

Recombinant Rat Integrin beta-1 (Itgb1), partial

MBS954230

0.01 mg (E-Coli)

200 USD

Recombinant Protein

Recombinant Rat Integrin beta-1 (Itgb1), partial

[Integrin beta-1 (Itgb1)]

[Beta oligodendroglia; Beta OL; Fibronectin receptor subunit beta; VLA-4 subunit beta; CD29]

[integrin beta-1; Integrin beta-1; integrin beta-1; integrin subunit beta 1; Beta oligodendroglia; Beta OL; Fibronectin receptor subunit beta; VLA-4 subunit beta; CD_antigen: CD29]

[Itgb1]

[Itgb1; Itgb1; Beta OL]

ITB1_RAT

E Coli or Yeast or Baculovirus or Mammalian Cell

[21-729. Partial,provide the complete extracellular domain.]

QTDKNRCLKANAKSCGECIQAGPNCGWCTNTTFLQEGMP
TSARCDDLEALKKKGCHPSDIENPRGSQTIKKNKNVTNR
SKGMAEKLRPEDITQIQPQQLLLKLRSGEPQKFTLKFKR
AEDYPIDLYYLMDLSYSMKDDLENVKSLGTDLMNEMRRI
TSDFRIGFGSFVEKTVMPYISTTPAKLRNPCTSEQNCTS
PFSYKNVLSLTDRGEFFNELVGQQRISGNLDSPEGGFDA
IMQVAVCGSLIGWRNVTRLLVFSTDAGFHFAGDGKLGGI
VLPNDGQCHLENNVYTMSHYYDYPSIAHLVQKLSENNIQ
TIFAVTEEFQPVYKELKNLIPKSAVGTLSGNSSNVIQLI
IDAYNSLSSEVILENSKLPDGVTINYKSYCKNGVNGTGE
NGRKCSNISIGDEVQFEISITANKCPNKESENQLKLNPL
GFTEEVEVVLQFICKCNCQSHGIPASPKCHEGNGTFECG
ACRCNEGRVGRHCECSTDEVNSEDMDAYCRKENSSEICS
NNGECVCGQCVCRKRENTNEIYSGKFCECDNFNCDRSNG
LICGGNGVCRCRVCECYPNYTGSACDCSLDTVPCVATNG
QICNGRGICECGACKCTDPKFQGPTCETCQTCLGVCAEH
KECVQCRAFNKGEKKDTCAQECSHFNLTKVESREKLPQP
VQVDPVTHCKEKDIDDCWFYFTYSVNSKGEAHVHVVETP
DCPTGPD

Greater than 90% as determined by SDS-PAGE.

Liquid containing glycerol

Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.

SDS-PAGE

Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha-11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha-4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin alpha-1/beta-1, alpha-2/beta-1, alpha-6/beta-1 and alpha-7/beta-1 are receptors for lamimin. Integrin alpha-4/beta-1 is a receptor for VCAM1 and recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. Integrin alpha-3/beta-1 is a receptor for epiligrin, thrombospondin and CSPG4. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. Integrin alpha-V/beta-1 is a receptor for vitronectin. Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands. When associated with alpha-7/beta-1 integrin, regulates cell adhesion and laminin matrix deposition. Involved in promoting endothelial cell motility and angiogenesis. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process and the formation of mineralized bone nodules. May be involved in up-regulation of the activity of kinases such as PKC via binding to KRT1. Together with KRT1 and GNB2L1, serves as a platform for SRC activation or inactivation. Plays a mechanistic adhesive role during telophase, required for the successful completion of cytokinesis.

Cloning and sequence of the cDNA encoding the rat oligodendrocyte integrin beta 1 subunit.Malek-Hedayat S., Rome L.H.Gene 158:287-290(1995)

158303324

NP_058718.2

NM_017022.2

P49134

94.4kD

Adaptive Immune System Pathway (1332755); Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway (117251); Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway (116129); Axon Guidance Pathway (83457); Axon Guidance Pathway (476); Axon Guidance Pathway (1333217); Bacterial Invasion Of Epithelial Cells Pathway (149774); Bacterial Invasion Of Epithelial Cells Pathway (148661); Basigin Interactions Pathway (1333069); Cell Adhesion Molecules (CAMs) Pathway (83461)

beta subunit of integrin receptor which binds collagen [RGD, Feb 2006]

ITGB1: an integral membrane protein that heterodimerizes with an alpha-3 chain, forming a receptor for many extracellular-matrix proteins including fibronectin, laminin, collagen, epiligrin and thrombospondin. Beta 1 integrins recognize the amino-acid motif RGD in a wide array of ligands. Five alternatively spliced variants with alternate carboxy termini have been described. Two alternatively spliced isoforms have been described. Isoform beta-1a is widely expressed; other isoforms are generally expressed with a more restricted distribution. Isoform beta-1b is expressed in skin, liver, skeletal muscle, cardiac muscle, placenta, umbilical vein endothelial cells, neuroblastoma cells, lymphoma cells, hepatoma cells and astrocytoma cells. Isoforms beta-1c and beta-1c-2 are expressed in muscle, kidney, liver, placenta, cervical epithelium, umbilical vein endothelial cells, fibroblast cells, embryonal kidney cells, platelets and several blood cell lines. Isoform beta-c-2, rather than isoform beta-1c, is selectively expressed in primary t-cells. Isoform beta-1c is expressed in nonproliferating and differentiated prostate gland epithelial cells. Isoform beta-1d is expressed specifically in striated muscle (skeletal and cardiac muscle). Protein type: Membrane protein, integral; Cell surface; Cell adhesion; Receptor, misc.; Motility/polarity/chemotaxis. Cellular Component: acrosome; adherens junction; basement membrane; cell surface; cytoplasm; cytoplasmic vesicle; dendritic spine; external side of plasma membrane; filopodium; focal adhesion; hemidesmosome; integrin complex; intercellular junction; lamellipodium; lipid raft; melanosome; membrane; neuromuscular junction; perinuclear region of cytoplasm; plasma membrane; receptor complex; recycling endosome; sarcolemma; synapse. Molecular Function: actin binding; alpha-actinin binding; cell adhesion molecule binding; collagen binding; fibronectin binding; glycoprotein binding; integrin binding; kinase binding; laminin binding; metal ion binding; peptide binding; protease binding; protein binding; protein complex binding; protein domain specific binding; protein heterodimerization activity; protein kinase binding; receptor activity; receptor binding. Biological Process: axon extension; calcium-independent cell-matrix adhesion; cardiac muscle cell differentiation; cardiac muscle development; cell adhesion; cell fate specification; cell migration; cell migration during sprouting angiogenesis; cell-cell adhesion mediated by integrin; cell-matrix adhesion; cell-substrate adhesion; cellular calcium ion homeostasis; dendrite morphogenesis; formation of radial glial scaffolds; G1/S transition of mitotic cell cycle; germ cell migration; heterotypic cell-cell adhesion; in utero embryonic development; integrin-mediated signaling pathway; leukocyte adhesion; leukocyte tethering or rolling; maternal process involved in pregnancy; mesodermal cell differentiation; negative regulation of cell differentiation; negative regulation of cell projection organization and biogenesis; negative regulation of cell proliferation; negative regulation of neuron differentiation; negative regulation of Rho protein signal transduction; neurite development; positive regulation of apoptosis; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of endocytosis; positive regulation of GTPase activity; positive regulation of MAPKKK cascade; positive regulation of neuron differentiation; positive regulation of peptidyl-tyrosine phosphorylation; protein transport within lipid bilayer; receptor internalization; regulation of cell cycle; regulation of G-protein coupled receptor protein signaling pathway; response to activity; response to drug; response to nutrient levels; sarcomere organization; stress fiber formation; tissue homeostasis; transforming growth factor beta receptor signaling pathway; visual learning

0.01 mg (E-Coli)

200 USD

0.05 mg (E-Coli)

260

0.1 mg (E-Coli)

430

0.2 mg (E-Coli)

685

0.5 mg (E-Coli)

1125

0.05 mg (Yeast)

1175

0.05 mg (Baculovirus)

1390

0.2 mg (Yeast)

1590

0.05 mg (Mammalian-Cell)

1630

1 mg (E-Coli)

1725

0.5 mg (Yeast)

1800

0.1 mg (Baculovirus)

2010

0.5 mg (Baculovirus)

2580

0.1 mg (Mammalian-Cell)

2605

1 mg (Yeast)

2825

1 mg (Baculovirus)

3985