catalog number :
MBS954093
products type :
Recombinant Protein
products full name :
Recombinant Human Interferon alpha-inducible protein 6
products short name :
Interferon alpha-inducible protein 6
products name syn :
Interferon-induced protein 6-16; Ifi-6-16
other names :
interferon alpha-inducible protein 6 isoform a; Interferon alpha-inducible protein 6; interferon alpha-inducible protein 6; interferon, alpha-inducible protein 6; Interferon-induced protein 6-16; Ifi-6-16
products gene name :
IFI6
other gene names :
IFI6; IFI6; 6-16; G1P3; FAM14C; IFI616; IFI-6-16; G1P3; Ifi-6-16
uniprot entry name :
IFI6_HUMAN
host :
E Coli or Yeast or Baculovirus or Mammalian Cell
sequence positions :
24-130
sequence :
GKKKCSESSDSGSGFWKALTFMAVGGGLAVAGLPALGFT
GAGIAANSVAASLMSWSAILNGGGVPAGGLVATLQSLGA
GGSSVVIGNIGALMGYATHKYLDSEEDEE
purity :
Greater than 90% as determined by SDS-PAGE.
form :
Liquid containing glycerol; lyophilization may be available upon request.
storage stability :
Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
products categories :
Metabolism
products references :
Characterization of a human gene inducible by alpha- and beta-interferons and its expression in mouse cells.Kelly J.M., Porter A.C.G., Chernajovsky Y., Gilbert C.S., Stark G.R., Kerr I.M.EMBO J. 5:1601-1606(1986)
ncbi acc num :
NP_002029.3
ncbi gb acc num :
NM_002038.3
ncbi pathways :
Cytokine Signaling In Immune System Pathway (1269310); Immune System Pathway (1269170); Interferon Signaling Pathway (1269311); Interferon Alpha/beta Signaling Pathway (1269312); Type II Interferon Signaling (IFNG) Pathway (198918)
ncbi summary :
This gene was first identified as one of the many genes induced by interferon. The encoded protein may play a critical role in the regulation of apoptosis. A minisatellite that consists of 26 repeats of a 12 nucleotide repeating element resembling the mammalian splice donor consensus sequence begins near the end of the second exon. Alternatively spliced transcript variants that encode different isoforms by using the two downstream repeat units as splice donor sites have been described. [provided by RefSeq, Jul 2008]
uniprot summary :
IFI6: first identified as one of the many genes induced by interferon. The encoded protein may play a critical role in the regulation of apoptosis. A minisatellite that consists of 26 repeats of a 12 nucleotide repeating element resembling the mammalian splice donor consensus sequence begins near the end of the second exon. Alternatively spliced transcript variants that encode different isoforms by using the two downstream repeat units as splice donor sites have been described. [provided by RefSeq, Jul 2008]. Protein type: Membrane protein, multi-pass; Membrane protein, integral; Apoptosis. Chromosomal Location of Human Ortholog: 1p35. Cellular Component: integral to membrane; mitochondrion; plasma membrane. Molecular Function: protein binding. Biological Process: cytokine and chemokine mediated signaling pathway; immune response; negative regulation of caspase activity; negative regulation of mitochondrial depolarization; release of cytochrome c from mitochondria