Recombinant Human Integrin beta-3 (ITGB3) | MyBioSource MBS953893 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human Integrin beta-3 (ITGB3)

catalog :

MBS953893

quantity :

0.5 mg (E-Coli)

price :

1510 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS953893

products type :

Recombinant Protein

products full name :

Recombinant Human Integrin beta-3 (ITGB3)

products short name :

Integrin beta-3 (ITGB3)

products name syn :

Integrin beta-3; Platelet membrane glycoprotein IIIa; GPIIIa; CD_antigen=; CD61

other names :

integrin beta-3; Integrin beta-3; integrin beta-3; platelet membrane glycoprotein IIIa; integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61); Platelet membrane glycoprotein IIIa; GPIIIa; CD_antigen: CD61

products gene name :

ITGB3

products gene name syn :

ITGB3; GP3A

other gene names :

ITGB3; ITGB3; GT; CD61; GP3A; BDPLT2; GPIIIa; BDPLT16; GP3A; GPIIIa

uniprot entry name :

ITB3_HUMAN

host :

E Coli or Yeast or Baculovirus or Mammalian Cell

sequence positions :

27-718, Partial, provide the complete extracellular domain.

sequence length :

718

sequence :

GPNICTTRGVSSCQQCLAVSPMCAWCSDEALPLGSPRCD
LKENLLKDNCAPESIEFPVSEARVLEDRPLSDKGSGDSS
QVTQVSPQRIALRLRPDDSKNFSIQVRQVEDYPVDIYYL
MDLSYSMKDDLWSIQNLGTKLATQMRKLTSNLRIGFGAF
VDKPVSPYMYISPPEALENPCYDMKTTCLPMFGYKHVLT
LTDQVTRFNEEVKKQSVSRNRDAPEGGFDAIMQATVCDE
KIGWRNDASHLLVFTTDAKTHIALDGRLAGIVQPNDGQC
HVGSDNHYSASTTMDYPSLGLMTEKLSQKNINLIFAVTE
NVVNLYQNYSELIPGTTVGVLSMDSSNVLQLIVDAYGKI
RSKVELEVRDLPEELSLSFNATCLNNEVIPGLKSCMGLK
IGDTVSFSIEAKVRGCPQEKEKSFTIKPVGFKDSLIVQV
TFDCDCACQAQAEPNSHRCNNGNGTFECGVCRCGPGWLG
SQCECSEEDYRPSQQDECSPREGQPVCSQRGECLCGQCV
CHSSDFGKITGKYCECDDFSCVRYKGEMCSGHGQCSCGD
CLCDSDWTGYYCNCTTRTDTCMSSNGLLCSGRGKCECGS
CVCIQPGSYGDTCEKCPTCPDACTFKKECVECKKFDRGA
LHDENTCNRYCRDEIESVKELKDTGKDAVNCTYKNEDDC
VVRFQYYEDSSGKSILYVVEEPECPKGPD

purity :

>90%

form :

Liquid containing glycerol; lyophilization may be available upon request.

storage stability :

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

other info1 :

Species: Homo sapiens (Human)

ncbi gi num :

47078292

ncbi acc num :

NP_000203.2

ncbi gb acc num :

NM_000212.2

uniprot acc num :

P05106

ncbi mol weight :

86,694 Da

ncbi pathways :

Arf6 Signaling Events Pathway (138034); Arrhythmogenic Right Ventricular Cardiomyopathy Pathway (672454); Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway (117293); Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway (116129); Axon Guidance Pathway (105688); Cell Surface Interactions At The Vascular Wall Pathway (106062); Developmental Biology Pathway (477129); Dilated Cardiomyopathy Pathway (121494); Dilated Cardiomyopathy Pathway (121285); ECM-receptor Interaction Pathway (83068)

ncbi summary :

The ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. [provided by RefSeq, Jul 2008]

uniprot summary :

ITGB3: integrin alpha-V/beta-3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIB/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIB/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIB/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha- IIB/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. Protein type: Cell adhesion; Motility/polarity/chemotaxis; Membrane protein, integral. Chromosomal Location of Human Ortholog: 17q21.32. Cellular Component: filopodium membrane; platelet alpha granule membrane; cell surface; focal adhesion; microvillus membrane; integral to plasma membrane; melanosome; plasma membrane; nucleus; integrin complex; receptor complex. Molecular Function: identical protein binding; protein binding; protease binding; extracellular matrix binding; vascular endothelial growth factor receptor 2 binding; fibronectin binding; platelet-derived growth factor receptor binding; protein disulfide isomerase activity; cell adhesion molecule binding; receptor activity. Biological Process: negative regulation of lipid transport; axon guidance; extracellular matrix organization and biogenesis; entry of virus into host cell; protein folding; wound healing; cell-matrix adhesion; smooth muscle cell migration; negative chemotaxis; mesodermal cell differentiation; positive regulation of vascular endothelial growth factor receptor signaling pathway; platelet degranulation; cell-substrate junction assembly; cell adhesion; cell growth; integrin-mediated signaling pathway; platelet activation; cell migration; regulation of bone resorption; negative regulation of lipoprotein metabolic process; angiogenesis involved in wound healing; cell-substrate adhesion; heterotypic cell-cell adhesion; positive regulation of peptidyl-tyrosine phosphorylation; negative regulation of low-density lipoprotein receptor biosynthetic process; activation of protein kinase activity; positive regulation of endothelial cell proliferation; positive regulation of protein amino acid phosphorylation; vascular endothelial growth factor receptor signaling pathway; tube development; blood coagulation; leukocyte migration. Disease: Glanzmann Thrombasthenia; Myocardial Infarction, Susceptibility To; Bleeding Disorder, Platelet-type, 16

size1 :

0.5 mg (E-Coli)

price1 :

1510 USD

size2 :

0.05 mg (Baculovirus)

price2 :

1510

size3 :

0.05 mg (Mammalian-Cell)

price3 :

1740

size4 :

0.5 mg (Yeast)

price4 :

1740

size5 :

1 mg (E-Coli)

price5 :

2515

more info or order :

MyBioSource product webpage