catalog number :
MBS953836
products type :
Recombinant Protein
products full name :
Recombinant Human Lupus La protein (SSB)
products short name :
Lupus La protein (SSB)
other names :
lupus La protein; Lupus La protein; lupus La protein; SS-B; autoantigen La; la autoantigen; SS-B/La protein; lupus La antigen; sjoegren syndrome type B antigen; La ribonucleoprotein domain family, member 3; Sjogren syndrome antigen B (autoantigen La); La autoantigen; La ribonucleoprotein; Sjoegren syndrome type B antigen; SS-B
other gene names :
SSB; SSB; La; LARP3; La/SSB; SS-B
uniprot entry name :
LA_HUMAN
host :
E Coli or Yeast or Baculovirus or Mammalian Cell
sequence positions :
1-408
sequence :
MAENGDNEKM AALEAKICHQ IEYYFGDFNL PRDKFLKEQI KLDEGWVPLE IMIKFNRLNR LTTDFNVIVE ALSKSKAELM EISEDKTKIR RSPSKPLPEV TDEYKNDVKN RSVYIKGFPT DATLDDIKEW LEDKGQVLNI QMRRTLHKAF KGSIFVVFDS IESAKKFVET PGQKYKETDL LILFKDDYFA KKNEERKQNK VEAKLRAKQE QEAKQKLEED AEMKSLEEKI GCLLKFSGDL DDQTCREDLH ILFSNHGEIK WIDFVRGAKE GIILFKEKAK EALGKAKDAN NGNLQLRNKE VTWEVLEGEV EKEALKKIIE DQQESLNKWK SKGRRFKGKG KGNKAAQPGS GKGKVQFQGK KTKFASDDEH DEHDENGATG PVKRAREETD KEEPASKQQK TENGAGDQ
storage stability :
Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
other info1 :
Tag Information: His tagged (Host tag may vary. Please inquire for specific tag information). Species: Homo sapiens (Human)
other info2 :
Storage Buffer: Tris-based buffer,50% glycerol. Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.
ncbi acc num :
NP_003133.1
ncbi gb acc num :
NM_003142.4
ncbi mol weight :
46,837 Da
ncbi pathways :
Gene Expression Pathway 105937!!RNA Polymerase I, RNA Polymerase III, And Mitochondrial Transcription Pathway 160948!!RNA Polymerase III Abortive And Retractive Initiation Pathway 160949!!RNA Polymerase III Transcription Pathway 106561!!RNA Polymerase III Transcription Termination Pathway 106567!!Systemic Lupus Erythematosus Pathway 83122!!Systemic Lupus Erythematosus Pathway 534
ncbi summary :
The protein encoded by this gene is involved in diverse aspects of RNA metabolism, including binding and protecting poly(U) termini of nascent RNA polymerase III transcripts from exonuclease digestion, processing 5' and 3' ends of pre-tRNA precursors, acting as an RNA chaperone, and binding viral RNAs associated with hepatitis C virus. Autoantibodies reacting with this protein are found in the sera of patients with Sjogren syndrome and systemic lupus erythematosus. Alternative promoter usage results in two different transcript variants which encode the same protein. [provided by RefSeq, Jun 2014]
size :
1 mg (E Coli Derived)