Recombinant Human Transcription factor ETV6 (ETV6) | MyBioSource MBS953409 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human Transcription factor ETV6 (ETV6)

catalog :

MBS953409

quantity :

0.5 mg (E-Coli)

price :

1230 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS953409

products type :

Recombinant Protein

products full name :

Recombinant Human Transcription factor ETV6 (ETV6)

products short name :

Transcription factor ETV6 (ETV6)

products name syn :

Transcription factor ETV6; ETS translocation variant 6; ETS-related protein Tel1; Tel

other names :

transcription factor ETV6; Transcription factor ETV6; transcription factor ETV6; TEL1 oncogene; ETS-related protein Tel1; ETS translocation variant 6; ets variant gene 6 (TEL oncogene); ets variant 6; ETS translocation variant 6; ETS-related protein Tel1; Tel

products gene name :

ETV6

products gene name syn :

ETV6; TEL; TEL1

other gene names :

ETV6; ETV6; TEL; TEL/ABL; TEL; TEL1; Tel

uniprot entry name :

ETV6_HUMAN

host :

E Coli or Yeast or Baculovirus or Mammalian Cell

sequence positions :

2-452

sequence length :

451

sequence :

SETPAQCSI KQERISYTPP ESPVPSYASS TPLHVPVPRA LRMEEDSIRL PAHLRLQPIY WSRDDVAQWL KWAENEFSLR PIDSNTFEMN GKALLLLTKE DFRYRSPHSG DVLYELLQHI LKQRKPRILF SPFFHPGNSI HTQPEVILHQ NHEEDNCVQR TPRPSVDNVH HNPPTIELLH RSRSPITTNH RPSPDPEQRP LRSPLDNMIR RLSPAERAQG PRPHQENNHQ ESYPLSVSPM ENNHCPASSE SHPKPSSPRQ ESTRVIQLMP SPIMHPLILN PRHSVDFKQS RLSEDGLHRE GKPINLSHRE DLAYMNHIMV SVSPPEEHAM PIGRIADCRL LWDYVYQLLS DSRYENFIRW EDKESKIFRI VDPNGLARLW GNHKNRTNMT YEKMSRALRH YYKLNIIRKE PGQRLLFRFM KTPDEIMSGR TDRLEHLESQ ELDEQIYQED EC

purity :

>90%

form :

Liquid containing glycerol; lyophilization may be available upon request.

storage stability :

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

other info1 :

Species: Homo sapiens (Human)

ncbi gi num :

4503611

ncbi acc num :

NP_001978.1

ncbi gb acc num :

NM_001987.4

uniprot acc num :

P41212

ncbi mol weight :

53,000 Da

ncbi pathways :

Diurnally Regulated Genes With Circadian Orthologs Pathway (198813); Dorso-ventral Axis Formation Pathway (114227); Dorso-ventral Axis Formation Pathway (472); Transcriptional Misregulation In Cancer Pathway (523016); Transcriptional Misregulation In Cancer Pathway (522987)

ncbi summary :

This gene encodes an ETS family transcription factor. The product of this gene contains two functional domains: a N-terminal pointed (PNT) domain that is involved in protein-protein interactions with itself and other proteins, and a C-terminal DNA-binding domain. Gene knockout studies in mice suggest that it is required for hematopoiesis and maintenance of the developing vascular network. This gene is known to be involved in a large number of chromosomal rearrangements associated with leukemia and congenital fibrosarcoma. [provided by RefSeq, Sep 2008]

uniprot summary :

Tel: Transcriptional repressor; binds to the DNA sequence 5 - CCGGAAGT-3 . A chromosomal aberration involving ETV6 is found in a form of chronic myelomonocytic leukemia (CMML). Translocation t(5;12)(q33;p13) with PDGFRB. It is characterized by abnormal clonal myeloid proliferation and by progression to acute myelogenous leukemia (AML). Chromosomal aberrations involving ETV6 are found in a form of acute myeloid leukemia (AML). Translocation t(12;22)(p13;q11) with MN1; translocation t(4;12)(q12;p13) with CHIC2. Chromosomal aberrations involving ETV6 are found in childhood acute lymphoblastic leukemia (ALL). Translocations t(12;21)(p12;q22) and t(12;21)(p13;q22) with RUNX1/AML1. A chromosomal aberration involving ETV6 is found in a form of pre-B acute myeloid leukemia. Translocation t(9;12)(p24;p13) with JAK2. A chromosomal aberration involving ETV6 is found in myelodysplastic syndrome (MDS) with basophilia. Translocation t(5;12)(q31;p13) with ACSL6. A chromosomal aberration involving ETV6 is found in acute eosinophilic leukemia (AEL). Translocation t(5;12)(q31;p13) with ACSL6. A chromosomal aberration involving ETV6 is found in myelodysplastic syndrome (MDS). Translocation t(1;12)(p36.1;p13) with MDS2. Defects in ETV6 are a cause of myeloproliferative disorder chronic with eosinophilia (MPE). A hematologic disorder characterized by malignant eosinophils proliferation. A chromosomal aberration involving ETV6 is found in many instances of myeloproliferative disorder chronic with eosinophilia. Translocation t(5;12) with PDGFRB on chromosome 5 creating an ETV6-PDGFRB fusion protein. Defects in ETV6 are a cause of acute myelogenous leukemia (AML). AML is a malignant disease in which hematopoietic precursors are arrested in an early stage of development. A chromosomal aberration involving ETV6 is found in acute lymphoblastic leukemia. Translocation t(9;12)(p13;p13) with PAX5. Belongs to the ETS family. Protein type: Transcription factor; Motility/polarity/chemotaxis; Oncoprotein; DNA-binding. Chromosomal Location of Human Ortholog: 12p13. Cellular Component: cytoplasm; nucleolus. Molecular Function: protein domain specific binding; protein binding; transcription factor activity. Biological Process: regulation of transcription from RNA polymerase II promoter; transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; cell differentiation. Disease: Thrombocytopenia 5

size1 :

0.5 mg (E-Coli)

price1 :

1230 USD

size2 :

0.05 mg (Baculovirus)

price2 :

1230

size3 :

0.5 mg (Yeast)

price3 :

1450

size4 :

0.05 mg (Mammalian-Cell)

price4 :

1450

size5 :

1 mg (E-Coli)

price5 :

2000

more info or order :

MyBioSource product webpage