protein

Recombinant Human Basement membrane-specific heparan sulfate proteoglycan core protein (HSPG2)

MBS953064

1 mg (E Coli Derived

1390 USD

Recombinant Protein

Recombinant Human Basement membrane-specific heparan sulfate proteoglycan core protein (HSPG2)

Basement membrane-specific heparan sulfate proteoglycan core protein(HSPG2)

basement membrane-specific heparan sulfate proteoglycan core protein isoform a; Basement membrane-specific heparan sulfate proteoglycan core protein; basement membrane-specific heparan sulfate proteoglycan core protein; perlecan proteoglycan; endorepellin (domain V region); heparan sulfate proteoglycan 2; Perlecan; PLC

HSPG2

HSPG2; HSPG2; PLC; SJA; SJS; HSPG; SJS1; PRCAN; HSPG; PLC

PGBM_HUMAN

E Coli or Yeast or Baculovirus or Mammalian Cell

>90%

Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.

Tag Information: His tagged (Host tag may vary. Please inquire for specific tag information). Species: Homo sapiens (Human)

Storage Buffer: Tris-based buffer,50% glycerol. Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.

629266065

NP_001278789.1

NM_001291860.1

P98160

468,830 Da

A Tetrasaccharide Linker Sequence Is Required For GAG Synthesis Pathway 645305!!Amyloids Pathway 366238!!Chondroitin Sulfate/dermatan Sulfate Metabolism Pathway 645308!!Chylomicron-mediated Lipid Transport Pathway 106157!!Degradation Of The Extracellular Matrix Pathway 576263!!Disease Pathway 530764!!Diseases Associated With Visual Transduction Pathway 771581!!ECM-receptor Interaction Pathway 83068!!ECM-receptor Interaction Pathway 479!!Extracellular Matrix Organization Pathway 576262

This gene encodes the perlecan protein, which consists of a core protein to which three long chains of glycosaminoglycans (heparan sulfate or chondroitin sulfate) are attached. The perlecan protein is a large multidomain proteoglycan that binds to and cross-links many extracellular matrix components and cell-surface molecules. It has been shown that this protein interacts with laminin, prolargin, collagen type IV, FGFBP1, FBLN2, FGF7 and transthyretin, etc., and it plays essential roles in multiple biological activities. Perlecan is a key component of the vascular extracellular matrix, where it helps to maintain the endothelial barrier function. It is a potent inhibitor of smooth muscle cell proliferation and is thus thought to help maintain vascular homeostasis. It can also promote growth factor (e.g., FGF2) activity and thus stimulate endothelial growth and re-generation. It is a major component of basement membranes, where it is involved in the stabilization of other molecules as well as being involved with glomerular permeability to macromolecules and cell adhesion. Mutations in this gene cause Schwartz-Jampel syndrome type 1, Silverman-Handmaker type of dyssegmental dysplasia, and tardive dyskinesia. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2014]

1 mg (E Coli Derived)

1390 USD