product summary
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company name :
MyBioSource
product type :
protein
product name :
Recombinant human Lipopolysaccharide-responsive and beige-like anchor protein
catalog :
MBS952535
quantity :
0.05 mg (E-Coli)
price :
195 USD
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS952535
products type :
Recombinant Protein
products full name :
Recombinant human Lipopolysaccharide-responsive and beige-like anchor protein
products short name :
Lipopolysaccharide-responsive and beige-like anchor protein
other names :
lipopolysaccharide-responsive and beige-like anchor protein isoform 1; Lipopolysaccharide-responsive and beige-like anchor protein; lipopolysaccharide-responsive and beige-like anchor protein; CDC4-like protein; vesicle trafficking, beach and anchor containing; LPS-responsive vesicle trafficking, beach and anchor containing; Beige-like protein; CDC4-like protein
other gene names :
LRBA; LRBA; BGL; LBA; CDC4L; CVID8; LAB300; BGL; CDC4L; LBA
uniprot entry name :
LRBA_HUMAN
host :
E Coli or Yeast or Baculovirus or Mammalian Cell
sequence :
ASEDNRVPSPPPTGDDGGGGGREETPTEGGALSLKPGLP
IRGIRMKFAVLTGLVEVGEVSNRDIVETVFNLLVGGQFD
LEMNFIIQEGESINCMVDLLEKCDITCQAEVWSMFTAIL
KKSIRNLQVCTEVGLVEKVLGKIEKVDNMIADLLVDMLG
VLASYNLTVRELKLFFSKLQGDKGRWPPHAGKLLSVLKH
MPQKYGPDAFFNFPGKSAAAIALPPIAKWPYQNGFTFHT
WLRMDPVNNINVDKDKP
storage stability :
Store at -20 degree C. For extended storage, conserve at -20 or -80 degree C.
ncbi gi num :
345498499
ncbi acc num :
NP_001186211.2
ncbi gb acc num :
NM_001199282.2
uniprot acc num :
P50851
ncbi mol weight :
319,108 Da
ncbi summary :
The protein encoded by this gene is a member of the WDL-BEACH-WD (WBW) gene family. Its expression is induced in B cells and macrophages by bacterial lipopolysaccharides (LPS). The encoded protein associates with protein kinase A and may be involved in leading intracellular vesicles to activated receptor complexes, which aids in the secretion and/or membrane deposition of immune effector molecules. Defects in this gene are associated with the disorder common variable immunodeficiency-8 with autoimmunity. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012]
uniprot summary :
LRBA: May be involved in coupling signal transduction and vesicle trafficking to enable polarized secretion and/or membrane deposition of immune effector molecules. Defects in LRBA are the cause of immunodeficiency, common variable, type 8, with autoimmunity (CVID8). An autosomal recessive immunologic disorder associated with defective B-cell differentiation and decreased or absent antibody production. Affected individuals have early-childhood onset of recurrent infections, particularly respiratory infections, and also develop variable autoimmune disorders, including idiopathic thrombocytopenic purpura, autoimmune hemolytic anemia, and inflammatory bowel disease. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral. Chromosomal Location of Human Ortholog: 4q31.3. Cellular Component: Golgi apparatus; extrinsic to membrane; membrane; lysosome; endoplasmic reticulum; cytoplasmic membrane-bound vesicle; integral to membrane; plasma membrane; endomembrane system. Molecular Function: phospholipid binding. Biological Process: endosome transport. Disease: Immunodeficiency, Common Variable, 8, With Autoimmunity
size1 :
0.05 mg (E-Coli)
price1 :
195 USD
size2 :
0.2 mg (E-Coli)
price2 :
465
size3 :
0.5 mg (E-Coli)
price3 :
815
size4 :
1 mg (E-Coli)
price4 :
1290
size5 :
1 mg (Yeast)
price5 :
2040
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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