catalog number :
MBS952480
products type :
Recombinant Protein
products full name :
Recombinant Human Elafin
products short name :
Elafin
products name syn :
Elastase-specific inhibitor; ESI; Peptidase inhibitor 3; PI-3; Protease inhibitor WAP3; Skin-derived antileukoproteinase; SKALPWAP four-disulfide core domain protein 14
other names :
elafin preproprotein; Elafin; elafin; peptidase inhibitor 3; Elastase-specific inhibitor; ESI; Peptidase inhibitor 3; PI-3; Protease inhibitor WAP3; Skin-derived antileukoproteinase; SKALP; WAP four-disulfide core domain protein 14
other gene names :
PI3; PI3; ESI; WAP3; SKALP; WFDC14; cementoin; WAP3; WFDC14; ESI; PI-3; SKALP
uniprot entry name :
ELAF_HUMAN
host :
E Coli or Yeast or Baculovirus or Mammalian Cell
sequence positions :
61-117
sequence :
AQEPVKGPVSTKPGSCPIILIRCAMLNPPNRCLKDTDCP
GIKKCCEGSCGMACFVPQ
purity :
Greater than 90% as determined by SDS-PAGE.
form :
Liquid containing glycerol; lyophilization may be available upon request.
storage stability :
Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
products categories :
Signal Transduction
products description :
Neutrophil and pancreatic elastase-specific inhibitor of skin. It may prevent elastase-mediated tissue proteolysis.
products references :
Primary structure of the human elafin precursor preproelafin deduced from the nucleotide sequence of its gene and the presence of unique repetitive sequences in the prosegment.Saheki T., Ito F., Hagiwara H., Saito Y., Kuroki J., Tachibana S., Hirose S.Biochem. Biophys. Res. Commun. 185:240-245(1992)
ncbi acc num :
NP_002629.1
ncbi gb acc num :
NM_002638.3
ncbi mol weight :
22.01kD
ncbi summary :
This gene encodes an elastase-specific inhibitor that functions as an antimicrobial peptide against Gram-positive and Gram-negative bacteria, and fungal pathogens. The protein contains a WAP-type four-disulfide core (WFDC) domain, and is thus a member of the WFDC domain family. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the centromeric cluster. Expression of this gene is upgulated by bacterial lipopolysaccharides and cytokines. [provided by RefSeq, Oct 2014]
uniprot summary :
elafin: Neutrophil and pancreatic elastase-specific inhibitor of skin. It may prevent elastase-mediated tissue proteolysis. Protein type: Secreted; Extracellular matrix; Inhibitor; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 20q13.12. Cellular Component: proteinaceous extracellular matrix. Molecular Function: endopeptidase inhibitor activity; serine-type endopeptidase inhibitor activity. Biological Process: copulation