protein

Recombinant Human Pituitary-specific positive transcription factor 1 (POU1F1)

MBS952420

0.5 mg (E-Coli)

1045 USD

Recombinant Protein

Recombinant Human Pituitary-specific positive transcription factor 1 (POU1F1)

Pituitary-specific positive transcription factor 1 (POU1F1)

Pituitary-specific positive transcription factor 1; PIT-1; Growth hormone factor 1; GHF-1

pituitary-specific positive transcription factor 1 isoform alpha; Pituitary-specific positive transcription factor 1; pituitary-specific positive transcription factor 1; growth hormone factor 1; POU domain, class 1, transcription factor 1; POU class 1 homeobox 1; Growth hormone factor 1; GHF-1

POU1F1

POU1F1; GHF1; PIT1

POU1F1; POU1F1; PIT1; CPHD1; GHF-1; Pit-1; POU1F1a; GHF1; PIT1; PIT-1; GHF-1

PIT1_HUMAN

E Coli or Yeast or Baculovirus or Mammalian Cell

1-291

291

MSCQAFTSAD TFIPLNSDAS ATLPLIMHHS AAECLPVSNH ATNVMSTATG LHYSVPSCHY GNQPSTYGVM AGSLTPCLYK FPDHTLSHGF PPIHQPLLAE DPTAADFKQE LRRKSKLVEE PIDMDSPEIR ELEKFANEFK VRRIKLGYTQ TNVGEALAAV HGSEFSQTTI CRFENLQLSF KNACKLKAIL SKWLEEAEQV GALYNEKVGA NERKRKRRTT ISIAAKDALE RHFGEQNKPS SQEIMRMAEE LNLEKEVVRV WFCNRRQREK RVKTSLNQSL FSISKEHLEC R

>90%

Liquid containing glycerol; lyophilization may be available upon request.

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Species: Homo sapiens (Human)

4505955

NP_000297.1

NM_000306.3

P28069

35,669 Da

Glucocorticoid Receptor Regulatory Network Pathway (138014)

This gene encodes a member of the POU family of transcription factors that regulate mammalian development. The protein regulates expression of several genes involved in pituitary development and hormone expression. Mutations in this genes result in combined pituitary hormone deficiency. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GHF-1: Transcription factor involved in the specification of the lactotrope, somatotrope, and thyrotrope phenotypes in the developing anterior pituitary. Activates growth hormone and prolactin genes. Specifically binds to the consensus sequence 5 - TAAAT-3 . Belongs to the POU transcription factor family. Class- 1 subfamily. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Transcription factor; DNA-binding. Chromosomal Location of Human Ortholog: 3p11. Cellular Component: nucleoplasm; cytoplasm. Molecular Function: chromatin binding; transcription factor activity; transcription corepressor activity. Biological Process: transcription from RNA polymerase II promoter; nuclear transport; regulation of insulin-like growth factor receptor signaling pathway; positive regulation of transcription, DNA-dependent; cell fate specification; positive regulation of inositol trisphosphate biosynthetic process; positive regulation of multicellular organism growth; negative regulation of transcription from RNA polymerase II promoter; determination of adult life span; negative regulation of cell proliferation; regulation of transcription, DNA-dependent; B cell differentiation; positive regulation of cell proliferation; somatotropin secreting cell development; positive regulation of transcription from RNA polymerase II promoter. Disease: Pituitary Hormone Deficiency, Combined, 1

0.5 mg (E-Coli)

1045 USD

0.05 mg (Baculovirus)

1045

0.5 mg (Yeast)

1275

0.05 mg (Mammalian-Cell)

1275

1 mg (E-Coli)

1625