catalog number :
MBS952121
products type :
Recombinant Protein
products full name :
Recombinant Human Glycerol-3-phosphate dehydrogenase, mitochondrial (GPD2)
products short name :
Glycerol-3-phosphate dehydrogenase, mitochondrial (GPD2)
products name syn :
Glycerol-3-phosphate dehydrogenase, mitochondrial; GPD-M; GPDH-M; EC=1.1.5.3; mtGPD
other names :
glycerol-3-phosphate dehydrogenase, mitochondrial; Glycerol-3-phosphate dehydrogenase, mitochondrial; glycerol-3-phosphate dehydrogenase, mitochondrial; GPD-M; mtGPD; GPDH-M; mitochondrial glycerophosphate dehydrogenase; glycerol-3-phosphate dehydrogenase 2 (mitochondrial); mtGPD
products gene name :
GPD2
other gene names :
GPD2; GPD2; GDH2; GPDM; mGPDH; GPD-M; GPDH-M
uniprot entry name :
GPDM_HUMAN
host :
E Coli or Yeast or Baculovirus or Mammalian Cell
sequence positions :
43-727
sequence :
ADCISEPV NREPPSREAQ LLTLQNTSEF DILVIGGGAT GSGCALDAVT RGLKTALVER DDFSSGTSSR STKLIHGGVR YLQKAIMKLD IEQYRMVKEA LHERANLLEI APHLSAPLPI MLPVYKWWQL PYYWVGIKLY DLVAGSNCLK SSYVLSKSRA LEHFPMLQKD KLVGAIVYYD GQHNDARMNL AIALTAARYG AATANYMEVV SLLKKTDPQT GKVRVSGARC KDVLTGQEFD VRAKCVINAT GPFTDSVRKM DDKDAAAICQ PSAGVHIVMP GYYSPESMGL LDPATSDGRV IFFLPWQKMT IAGTTDTPTD VTHHPIPSEE DINFILNEVR NYLSCDVEVR RGDVLAAWSG IRPLVTDPKS ADTQSISRNH VVDISESGLI TIAGGKWTTY RSMAEDTINA AVKTHNLKAG PSRTVGLFLQ GGKDWSPTLY IRLVQDYGLE SEVAQHLAAT YGDKAFEVAK MASVTGKRWP IVGVRLVSEF PYIEAEVKYG IKEYACTAVD MISRRTRLAF LNVQAAEEAL PRIVELMGRE LNWDDYKKQE QLETARKFLY YEMGYKSRSE QLTDRSEISL LPSDIDRYKK RFHKFDADQK GFITIVDVQR VLESINVQMD ENTLHEILNE VDLNKNGQVE LNEFLQLMSA IQKGRVSGSR LAILMKTAEE NLDRRVPIPV DRSCGGL
form :
Liquid containing glycerol; lyophilization may be available upon request.
storage stability :
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
other info1 :
Species: Homo sapiens (Human)
products description :
sn-glycerol 3-phosphate + a quinone = glycerone phosphate + a quinol.
ncbi acc num :
NP_000399.3
ncbi gb acc num :
NM_000408.4
ncbi pathways :
CDP-diacylglycerol Biosynthesis I Pathway (142255); Fatty Acid Beta Oxidation Pathway (198865); Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway (160977); Glycerophospholipid Metabolism Pathway (82989); Glycerophospholipid Metabolism Pathway (364); Metabolism Pathway (477135); Metabolism Of Lipids And Lipoproteins Pathway (160976); Glycerol-3-phosphate Shuttle Pathway (545367); Glycerol-3-phosphate Shuttle Pathway (139739); Phosphatidylglycerol Biosynthesis II (non-plastidic) Pathway (142264)
ncbi summary :
The protein encoded by this gene localizes to the inner mitochondrial membrane and catalyzes the conversion of glycerol-3-phosphate to dihydroxyacetone phosphate, using FAD as a cofactor. Along with GDP1, the encoded protein constitutes the glycerol phosphate shuttle, which reoxidizes NADH formed during glycolysis. Two transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Jan 2010]
uniprot summary :
GPD2: localizes to the inner mitochondrial membrane and catalyzes the conversion of glycerol-3-phosphate to dihydroxyacetone phosphate, using FAD as a cofactor. Along with GDP1, the encoded protein constitutes the glycerol phosphate shuttle, which reoxidizes NADH formed during glycolysis. Two transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Jan 2010]. Protein type: EC 1.1.5.3; Mitochondrial; Oxidoreductase; Calcium-binding; Lipid Metabolism - glycerophospholipid. Chromosomal Location of Human Ortholog: 2q24.1. Cellular Component: glycerol-3-phosphate dehydrogenase complex; mitochondrial inner membrane. Molecular Function: glycerol-3-phosphate dehydrogenase activity; calcium ion binding. Biological Process: glycerol-3-phosphate metabolic process; camera-type eye development; multicellular organism growth; cellular lipid metabolic process; gluconeogenesis; glycerol catabolic process. Disease: Diabetes Mellitus, Noninsulin-dependent
size2 :
0.05 mg (Baculovirus)
size4 :
0.05 mg (Mammalian-Cell)