product summary
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company name :
MyBioSource
product type :
protein
product name :
Recombinant Human Squalene synthase
catalog :
MBS951511
quantity :
0.01 mg (E-Coli)
price :
110 USD
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS951511
products type :
Recombinant Protein
products full name :
Recombinant Human Squalene synthase
products short name :
Squalene synthase
products name syn :
FPP: FPP farnesyltransferase Farnesyl-diphosphate farnesyltransferase
other names :
squalene synthase isoform 1; Squalene synthase; squalene synthase; farnesyl-diphosphate farnesyltransferase 1; FPP:FPP farnesyltransferase; Farnesyl-diphosphate farnesyltransferase
products gene name :
FDFT1
other gene names :
FDFT1; FDFT1; SS; SQS; DGPT; ERG9; SQS; SS
uniprot entry name :
FDFT_HUMAN
host :
E Coli or Yeast or Baculovirus or Mammalian Cell
sequence positions :
2-417
sequence length :
374
sequence :
EFVKCLGHPEEFYNLVRFRIGGKRKVMPKMDQDSLSSSL
KTCYRYLNQTSRSFAAVIQALDGEMRNAVCIFYLVLRAL
DTLEDDMTISVEKKVPLLHNFHSFLYQPDWRFMESKEKD
RQVLEDFPTISLEFRNLAEKYQTVIADICRRMGIGMAEF
LDKHVTSEQEWDKYCHYVAGLVGIGLSRLFSASEFEDPL
VGEDTERANSMGLFLQKTNIIRDYLEDQQGGREFWPQEV
WSRYVKKLGDFAKPENIDLAVQCLNELITNALHHIPDVI
TYLSRLRNQSVFNFCAIPQVMAIATLAACYNNQQVFKGA
VKIRKGQAVTLMMDATNMPAVKAIIYQYMEEIYHRIPDS
DPSSSKTRQIISTIRTQNLPNCQLISRSHYSPIYLSFVM
LLAALSWQYLTTLSQVTEDYVQTGEH
purity :
Greater than 90% as determined by SDS-PAGE.
form :
Liquid containing glycerol; lyophilization may be available upon request.
storage stability :
Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
other info2 :
Species: Homo sapiens (Human)
products categories :
Metabolism
products description :
2 farnesyl diphosphate + NAD(P)H = squalene + 2 diphosphate + NAD(P)+.
products references :
Expression, purification, and characterization of the human squalene synthase: use of yeast and baculoviral systems." Soltis D.A., McMahon G., Caplan S.L., Dudas D.A., Chamberlin H.A., Vattay A., Dottavio D., Rucker M.L., Engstrom R.G., Cornell-Kennon S.A. Arch. Biochem. Biophys. 316:713-723(1995)
ncbi gi num :
567757574
ncbi acc num :
NP_001274671.1
ncbi gb acc num :
NM_001287742.1
uniprot acc num :
P37268
ncbi mol weight :
47.76kD
ncbi pathways :
Activation Of Gene Expression By SREBF (SREBP) Pathway (1270039); Cholesterol Biosynthesis Pathway (198809); Cholesterol Biosynthesis Pathway (1270037); Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway (1270010); Metabolic Pathways (132956); Metabolism Pathway (1269956); Metabolism Of Lipids And Lipoproteins Pathway (1270001); PPARA Activates Gene Expression Pathway (1270030); Regulation Of Cholesterol Biosynthesis By SREBP (SREBF) Pathway (1270038); Regulation Of Lipid Metabolism By Peroxisome Proliferator-activated Receptor Alpha (PPARalpha) Pathway (1270029)
ncbi summary :
This gene encodes a membrane-associated enzyme located at a branch point in the mevalonate pathway. The encoded protein is the first specific enzyme in cholesterol biosynthesis, catalyzing the dimerization of two molecules of farnesyl diphosphate in a two-step reaction to form squalene. [provided by RefSeq, Jul 2008]
uniprot summary :
FDFT1: a membrane-associated enzyme located at a branch point in the mevalonate pathway. The encoded protein is the first specific enzyme in cholesterol biosynthesis, catalyzing the dimerization of two molecules of farnesyl diphosphate in a two-step reaction to form squalene. [provided by RefSeq, Jul 2008]. Protein type: EC 2.5.1.21; Membrane protein, integral; Membrane protein, multi-pass; Transferase; Lipid Metabolism - steroid biosynthesis; Oxidoreductase; Endoplasmic reticulum. Chromosomal Location of Human Ortholog: 8p23.1-p22. Cellular Component: endoplasmic reticulum; endoplasmic reticulum membrane; integral to membrane. Molecular Function: farnesyl-diphosphate farnesyltransferase activity; oxidoreductase activity. Biological Process: cellular lipid metabolic process; cholesterol biosynthetic process; farnesyl diphosphate metabolic process; isoprenoid biosynthetic process; steroid biosynthetic process
size1 :
0.01 mg (E-Coli)
price1 :
110 USD
size2 :
0.05 mg (E-Coli)
price2 :
190
size3 :
0.2 mg (E-Coli)
price3 :
460
size4 :
0.5 mg (E-Coli)
price4 :
750
size5 :
0.5 mg (Yeast)
price5 :
1170
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
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