protein

Recombinant Human POU domain, class 6, transcription factor 2 (POU6F2)

MBS951275

0.5 mg (E-Coli)

1495 USD

Recombinant Protein

Recombinant Human POU domain, class 6, transcription factor 2 (POU6F2)

POU domain, class 6, transcription factor 2 (POU6F2)

POU domain, class 6, transcription factor 2; Retina-derived POU domain factor 1; RPF-1

POU domain, class 6, transcription factor 2 isoform 2; POU domain, class 6, transcription factor 2; Retina-derived POU domain factor 1; RPF-1

POU6F2

POU6F2; RPF1

POU6F2; RPF1; RPF-1

PO6F2_HUMAN

E Coli or Yeast or Baculovirus or Mammalian Cell

1-691

691

MSALLQDPMI AGQVSKPLLS VRSEMNAELR GEDKAATSDS ELNEPLLAPV ESNDSEDTPS KLFGARGNPA LSDPGTPDQH QASQTHPPFP VGPQPLLTAQ QLASAVAGVM PGGPPALNQP ILIPFNMAGQ LGGQQGLVLT LPTANLTNIQ GLVAAAAAGG IMTLPLQNLQ ATSSLNSQLQ QLQLQLQQQQ QQQQQQPPPS TNQHPQPAPQ APSQSQQQPL QPTPPQQPPP ASQQPPAPTS QLQQAPQPQQ HQPHSHSQNQ NQPSPTQQSS SPPQKPSQSP GHGLPSPLTP PNPLQLVNNP LASQAAAAAA AMSSIASSQA FGNALSSLQG VTGQLVTNAQ GQIIGTIPLM PNPGPSSQAA SGTQGLQVQP ITPQLLTNAQ GQIIATVIGN QILPVINTQG ITLSPIKPGQ QLHQPSQTSV GQAASQGNLL HLAHSQASMS QSPVRQASSS SSSSSSSSAL SVGQLVSNPQ TAAGEVDGVN LEEIREFAKA FKIRRLSLGL TQTQVGQALS ATEGPAYSQS AICRHTILRS HFFLPQEAQE NTIASSLTAK LNPGLLYPAR FEKLDITPKS AQKIKPVLER WMAEAEARHR AGMQNLTEFI GSEPSKKRKR RTSFTPQALE ILNAHFEKNT HPSGQEMTEI AEKLNYDREV VRVWFCNKRQ ALKNTIKRLK QHEPATAVPL EPLTDSLEEN S

>90%

Liquid containing glycerol; lyophilization may be available upon request.

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Species: Homo sapiens (Human)

260436858

NP_001159490.1

NM_001166018.1

P78424

69,248 Da

This gene encodes a member of the POU protein family characterized by the presence of a bipartite DNA binding domain, consisting of a POU-specific domain and a homeodomain, separated by a variable polylinker. The DNA binding domain may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner. The POU family members are transcriptional regulators, many of which are known to control cell type-specific differentiation pathways. This gene is a tumor suppressor involved in Wilms tumor (WT) predisposition. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[provided by RefSeq, Oct 2009]

POU6F2: Probable transcription factor likely to be involved in early steps in the differentiation of amacrine and ganglion cells. Recognizes and binds to the DNA sequence 5 -ATGCAAAT-3 . Isoform 1 does not bind DNA. Defects in POU6F2 are a cause of hereditary susceptibility to Wilms tumor 5 (WT5). WT5 is a pediatric malignancy of kidney and one of the most common solid cancers in childhood. Belongs to the POU transcription factor family. Class- 6 subfamily. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Transcription factor; Cell development/differentiation; DNA-binding. Chromosomal Location of Human Ortholog: 7p14.1. Cellular Component: nucleus. Molecular Function: DNA binding; transcription factor activity. Biological Process: transcription from RNA polymerase II promoter; central nervous system development; regulation of transcription, DNA-dependent; visual perception; ganglion mother cell fate determination. Disease: Wilms Tumor 5

0.5 mg (E-Coli)

1495 USD

0.05 mg (Baculovirus)

1495

0.5 mg (Yeast)

1725

0.05 mg (Mammalian-Cell)

1725

1 mg (E-Coli)

2555