Recombinant Human C-C chemokine receptor type 2 (CCR2) | MyBioSource MBS951130 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human C-C chemokine receptor type 2 (CCR2)

catalog :

MBS951130

quantity :

1 mg (E-Coli)

price :

1090 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS951130

products type :

Recombinant Protein

products full name :

Recombinant Human C-C chemokine receptor type 2 (CCR2)

products short name :

C-C chemokine receptor type 2 (CCR2)

products name syn :

Recombinant C-C chemokine receptor type 2 (CCR2); C-C chemokine receptor type 2; C-C CKR-2; CC-CKR-2; CCR-2; CCR2; Monocyte chemoattractant protein 1 receptor; MCP-1-R CD_antigen= CD192

other names :

C-C chemokine receptor type 2 isoform A; C-C chemokine receptor type 2; C-C chemokine receptor type 2; MCP-1 receptor; monocyte chemotactic protein 1 receptor; monocyte chemoattractant protein 1 receptor; chemokine (C-C motif) receptor 2; Monocyte chemoattractant protein 1 receptor

products gene name syn :

CCR2; CMKBR2

other gene names :

CCR2; CCR2; CKR2; CCR-2; CCR2A; CCR2B; CD192; CKR2A; CKR2B; CMKBR2; MCP-1-R; CC-CKR-2; CMKBR2; C-C CKR-2; CC-CKR-2; CCR-2; CCR2; MCP-1-R

uniprot entry name :

CCR2_HUMAN

host :

E Coli or Yeast or Baculovirus or Mammalian Cell

sequence positions :

310-374

purity :

>90%

form :

Liquid containing glycerol; lyophilization may be available upon request.

storage stability :

Store at -20 degree C. For extended storage, store at -20 or -80 degree C.

other info1 :

Species: Homo sapiens (Human)

ncbi gi num :

183979980

ncbi acc num :

NP_001116513.2

ncbi gb acc num :

NM_001123041.2

uniprot acc num :

P41597

ncbi mol weight :

41,915 Da

ncbi pathways :

Beta Defensins Pathway (530759); Chemokine Receptors Bind Chemokines Pathway (106359); Chemokine Signaling Pathway (99051); Chemokine Signaling Pathway (96864); Class A/1 (Rhodopsin-like Receptors) Pathway (106357); Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); Defensins Pathway (530757); G Alpha (i) Signalling Events Pathway (119550); GPCR Downstream Signaling Pathway (119548)

ncbi summary :

This gene encodes two isoforms of a receptor for monocyte chemoattractant protein-1, a chemokine which specifically mediates monocyte chemotaxis. Monocyte chemoattractant protein-1 is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors. The receptors encoded by this gene mediate agonist-dependent calcium mobilization and inhibition of adenylyl cyclase. This gene is located in the chemokine receptor gene cluster region. Two alternatively spliced transcript variants are expressed by the gene. [provided by RefSeq, Mar 2009]

uniprot summary :

CCR2: a seven transmembrane protein closely related to CCR1. Receptor for the MCP-1, MCP-3 and MCP-4 chemokines. Expressed at high levels in primary neutrophils and primary monocytes, and is further upregulated on neutrophil activation and during monocyte to macrophage differentiation. Transduces a signal by increasing the intracellular calcium ions level. Alternative co receptor with CD4 for HIV-1 infection. Two splice-variant isoforms have been described. Protein type: Membrane protein, integral; Receptor, GPCR; GPCR, family 1; Membrane protein, multi-pass. Chromosomal Location of Human Ortholog: 3p21.31. Cellular Component: cell soma; perinuclear region of cytoplasm; integral to plasma membrane; dendrite; cytoplasm; integral to membrane; plasma membrane; perikaryon; cytosol. Molecular Function: protein homodimerization activity; CCR2 chemokine receptor binding; C-C chemokine receptor activity; chemokine receptor activity. Biological Process: positive regulation of T-helper 1 type immune response; viral reproduction; chemotaxis; elevation of cytosolic calcium ion concentration; response to wounding; dendritic cell chemotaxis; cellular homeostasis; inflammatory response; positive regulation of tumor necrosis factor biosynthetic process; cytokine and chemokine mediated signaling pathway; negative regulation of adenylate cyclase activity; JAK-STAT cascade; cellular calcium ion homeostasis; G-protein coupled receptor protein signaling pathway; negative regulation of angiogenesis; positive regulation of interferon-gamma production; negative regulation of T-helper 2 type immune response; positive regulation of interleukin-2 production; cellular defense response; innate immune response; blood vessel remodeling; positive regulation of alpha-beta T cell proliferation; immune response; negative regulation of eosinophil degranulation; positive regulation of T cell activation; positive regulation of inflammatory response

size1 :

1 mg (E-Coli)

price1 :

1090 USD

size2 :

1 mg (Yeast)

price2 :

1540

more info or order :

MyBioSource product webpage