Recombinant Carbonyl reductase [NADPH] 1 | MyBioSource MBS951085 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Carbonyl reductase [NADPH] 1

catalog :

MBS951085

quantity :

0.05 mg (E-Coli)

price :

190 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS951085

products type :

Recombinant Protein

products full name :

Recombinant Carbonyl reductase [NADPH] 1

products short name :

Carbonyl reductase [NADPH] 1

products name syn :

15-hydroxyprostaglandin dehydrogenase [NADP(+)] (EC:1.1.1.197); NADPH-dependent carbonyl reductase 1; Prostaglandin 9-ketoreductase; Prostaglandin-E(2) 9-reductase (EC:1.1.1.189); Short chain dehydrogenase/reductase family 21C member 1

other names :

carbonyl reductase; Carbonyl reductase [NADPH] 1; carbonyl reductase [NADPH] 1; carbonyl reductase 1; 15-hydroxyprostaglandin dehydrogenase [NADP(+)] (EC:1.1.1.197); NADPH-dependent carbonyl reductase 1; Prostaglandin 9-ketoreductase; Prostaglandin-E(2) 9-reductase (EC:1.1.1.189); Short chain dehydrogenase/reductase family 21C member 1

products gene name :

CBR1

other gene names :

CBR1; CBR1; CBR; hCBR1; SDR21C1; CBR; CRN; SDR21C1

uniprot entry name :

CBR1_HUMAN

host :

E Coli or Yeast or Baculovirus or Mammalian Cell

sequence positions :

45-320

sequence length :

173

sequence :

SSGIHVALVTGGNKGIGLAIVRDLCRLFSGDVVLTARDV
TRGQAAVQQLQAEGLSPRFHQLDIDDLQSIRALRDFLRK
EYGGLDVLVNNAGIAFKVADPTPFHIQAEVTMKTNFFGT
RDVCTELLPLIKPQGRVVNVSSIMSVRALKSCSPELQQK
FRSETITEEELVGLMNKFVEDTKKGVHQKEGWPSSAYGV
TKIGVTVLSRIHARKLSEQRKGDKILLNACCPGWVRTDM
AGPKATKSPEEGAETPVYLAL

purity :

Greater than 90% as determined by SDS-PAGE.

form :

Liquid containing glycerol; lyophilization may be available upon request.

storage stability :

Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.

products categories :

Metabolism

products description :

NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E2 to prostaglandin F2-alpha. Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione.

products references :

Human carbonyl reductase. Nucleotide sequence analysis of a cDNA and amino acid sequence of the encoded protein.Wermuth B., Bohren K.M., Heinemann G., von Wartburg J.-P., Gabbay K.H.J. Biol. Chem. 263:16185-16188(1988)

ncbi gi num :

557948119

ncbi acc num :

NP_001273718.1

ncbi gb acc num :

NM_001286789.1

uniprot acc num :

P16152

ncbi mol weight :

32.2kD

ncbi pathways :

Arachidonic Acid Metabolism Pathway (82991); Arachidonic Acid Metabolism Pathway (1270087); Arachidonic Acid Metabolism Pathway (366); Chemical Carcinogenesis Pathway (673221); Chemical Carcinogenesis Pathway (673237); Metabolic Pathways (132956); Metabolism Pathway (1269956); Metabolism Of Lipids And Lipoproteins Pathway (1270001); Metabolism Of Xenobiotics By Cytochrome P450 Pathway (83031); Metabolism Of Xenobiotics By Cytochrome P450 Pathway (425)

ncbi summary :

The protein encoded by this gene belongs to the short-chain dehydrogenases/reductases (SDR) family, which function as NADPH-dependent oxidoreductases having wide specificity for carbonyl compounds, such as quinones, prostaglandins, and various xenobiotics. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2013]

uniprot summary :

CBR1: NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E2 to prostaglandin F2-alpha. Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione. Belongs to the short-chain dehydrogenases/reductases (SDR) family. Protein type: EC 1.1.1.189; EC 1.1.1.197; Lipid Metabolism - arachidonic acid; EC 1.1.1.184; Oxidoreductase. Chromosomal Location of Human Ortholog: 21q22.13. Cellular Component: cytosol. Molecular Function: 15-hydroxyprostaglandin dehydrogenase (NADP+) activity; carbonyl reductase (NADPH) activity; oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor; prostaglandin-E2 9-reductase activity. Biological Process: arachidonic acid metabolic process; cyclooxygenase pathway; drug metabolic process; epithelial cell differentiation; vitamin K metabolic process

size1 :

0.05 mg (E-Coli)

price1 :

190 USD

size2 :

0.2 mg (E-Coli)

price2 :

460

size3 :

0.5 mg (E-Coli)

price3 :

750

size4 :

0.05 mg (Baculovirus)

price4 :

1030

size5 :

1 mg (E-Coli)

price5 :

1180

more info or order :

MyBioSource product webpage