catalog number :
MBS950941
products type :
Recombinant Protein
products full name :
Recombinant Mouse CD82 antigen
products short name :
CD82 antigen
products name syn :
C33 antigen; IA4; Inducible membrane protein R2; Metastasis suppressor Kangai-1 homolog; CD82
other names :
CD82 antigen; CD82 antigen; CD82 antigen; CD82 antigen; C33 antigen; IA4; Inducible membrane protein R2; Metastasis suppressor Kangai-1 homolog; CD_antigen: CD82
products gene name :
Cd82
other gene names :
Cd82; Cd82; C33; IA4; Kai1; Tspan27; AA682076; AL023070; Kai1
uniprot entry name :
CD82_MOUSE
host :
E Coli or Yeast or Baculovirus or Mammalian Cell
sequence positions :
111-227
sequence :
DKLKKEMGNTVMDIIRNYTANATSSREEAWDYVQAQVKC
CGWVSHYNWTENEELMGFTKTTYPCSCEKIKEEDNQLIV
KKGFCEADNSTVSENNPEDWPVNTEGCMEKAQAWLQENF
purity :
Greater than 90% as determined by SDS-PAGE.
form :
Liquid containing glycerol; lyophilization may be available upon request.
storage stability :
Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
products description :
Associates with CD4 or CD8 and delivers costimulatory signals for the TCR/CD3 pathway.
products references :
Mouse homologue of C33 antigen (CD82)
, a member of the transmembrane 4 superfamily
complementary DNA, genomic structure, and expression.Nagira M., Imai T., Ishikawa I., Uwabe K.I., Yoshie O.Cell. Immunol. 157:144-157(1994)
The mouse C2C12 myoblast cell surface N-linked glycoproteome
identification, glycosite occupancy, and membrane orientation.Gundry R.L., Raginski K., Tarasova Y., Tchernyshyov I., Bausch-Fluck D., Elliott S.T., Boheler K.R., Van Eyk J.E., Wollscheid B.Mol. Cell. Proteomics 8:2555-2569(2009)
ncbi acc num :
NP_001129527.1
ncbi gb acc num :
NM_001136055.2
ncbi pathways :
P53 Signaling Pathway (83252); P53 Signaling Pathway (465)
uniprot summary :
CD82: a widespread transmembrane protein of the tetraspanin family. A metastasis-suppressor whose decreased expression may be involved in malignant progression. Suppresses tumor metastasis of many cancers including cancers of the prostate, bladder, colon, cervix, liver, and lung (NSCLC). It is a target of estrogen receptor-mediated gene repression and is downregulated in primary human breast cancer. May be a prognostic marker for lung cancer and tumor metastatic potential. Interacts with cell surface proteins including integrins, cadherins, CD4, CD8, IGSF8. Modulates EGFR signaling. May suppress invasion by inhibiting integrin-dependent crosstalk with c-Met receptor and Src kinases. Its regulation of c-Met signaling apparently affects cancer cell migration. Protein type: Membrane protein, integral; Membrane protein, multi-pass; Cell surface. Cellular Component: integral to membrane; integral to plasma membrane; membrane. Biological Process: cell surface receptor linked signal transduction