catalog number :
MBS9509113
products full name :
5-HT-6 Antibody
products short name :
[5-HT-6]
products name syn :
[5-HT6; 5HT6R; HTR6]
other names :
[5-hydroxytryptamine receptor 6; 5-hydroxytryptamine receptor 6; 5-hydroxytryptamine receptor 6; 5-hydroxytryptamine receptor 6; Serotonin receptor 6]
products gene name :
[5-HT-6]
products gene name syn :
[HTR6]
other gene names :
[HTR6; HTR6; 5-HT6; 5-HT6R; 5-HT-6; 5-HT6]
reactivity :
Human, Mouse, Rat
specificity :
5-HT-6 Antibody detects endogenous levels of 5-HT-6.
purity :
The antibody was purified from rabbit antiserum by affinity chromatography using immunogen.
form :
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
storage stability :
Stable at -20°C for at least 1 year.
tested application :
Western Blot (WB), ELISA (EIA)
app notes :
WB: 1:500~1:1000. ELISA: 1:10000
image1 heading :
Western Blot (WB)
other info1 :
Target Modification: Unmodified/Total
other info2 :
Immunogen: The antiserum was produced against synthesized peptide derived from human 5-HT-6.
ncbi acc num :
NP_000862.1
ncbi gb acc num :
NM_000871.2
ncbi pathways :
Amine Ligand-binding Receptors Pathway (106363); Calcium Signaling Pathway (83050); Calcium Signaling Pathway (459); Class A/1 (Rhodopsin-like Receptors) Pathway (106357); G Alpha (s) Signalling Events Pathway (119549); GPCR Downstream Signaling Pathway (119548); GPCR Ligand Binding Pathway (161020); GPCRs, Class A Rhodopsin-like Pathway (198886); Monoamine GPCRs Pathway (198861); Neuroactive Ligand-receptor Interaction Pathway (83053)
ncbi summary :
This gene encodes a protein that belongs to the seven-transmembrane G protein-coupled receptor family of proteins. The encoded protein couples with the Gs alpha subunit and stimulates adenylate cyclase to activate the cyclic AMP-dependent signaling pathway. This receptor is thought to regulate cholinergic neuronal transmission in the brain. Several antidepressants and antipsychotic drugs have a high affinity for this receptor. [provided by RefSeq, Aug 2013]
uniprot summary :
This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. It has a high affinity for tricyclic psychotropic drugs (). Controls pyramidal neurons migration during corticogenesis, through the regulation of CDK5 activity (). Is an activator of TOR signaling (PubMed:23027611).