protein

Recombinant Rat Complement C5 (C5)

MBS950846

0.5 mg (E-Coli)

805 USD

Recombinant Protein

Recombinant Rat Complement C5 (C5)

Complement C5 (C5)

Complement C5Cleaved into the following chain:; 1. C5a anaphylatoxin

Complement C5; Complement C5; complement C5; anaphylatoxin; complement component 5

C5

C5; C5; Hc; C5a; RGD1561905

CO5_RAT

E Coli or Yeast or Baculovirus or Mammalian Cell

Jan-77

77

DLQLLHQKVE EQAAKYKHRV PKKCCYDGAR ENKYETCEQR VARVTIGPHC IRAFNECCTI ADKIRKESHH KGMLLGR

>90%

Liquid containing glycerol; lyophilization may be available upon request.

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Species: Rattus norvegicus (Rat)

C5

46397770

P08650.2

P08650

8,981 Da

Activation Of C3 And C5 Pathway (1010995); Class A/1 (Rhodopsin-like Receptors) Pathway (1010164); Complement Activation, Classical Pathway (198509); Complement And Coagulation Cascades Pathway (83465); Complement And Coagulation Cascades Pathway (484); Complement Cascade Pathway (1010988); G Alpha (i) Signalling Events Pathway (1010195); GPCR Downstream Signaling Pathway (1010193); GPCR Ligand Binding Pathway (1010163); Herpes Simplex Infection Pathway (377869)

likely component of the classical pathway of the complement cascade; may be involved with tissue injury associated with ischemia or sepsis; may be a component of the membrane attack complex [RGD, Feb 2006]

C5: Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled. Defects in C5 are the cause of complement component 5 deficiency (C5D). A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis. An association study of C5 haplotypes and genotypes in individuals with chronic hepatitis C virus infection shows that individuals homozygous for the C5_1 haplotype have a significantly higher stage of liver fibrosis than individuals carrying at least 1 other allele (PubMed:15995705). Protein type: Secreted, signal peptide; Secreted. Cellular Component: extracellular space. Molecular Function: C5a anaphylatoxin chemotactic receptor binding. Biological Process: cellular calcium ion homeostasis; positive regulation of angiogenesis; in utero embryonic development; positive regulation of chemotaxis; complement activation, alternative pathway; negative regulation of dopamine secretion; inflammatory response; chemotaxis; glucose homeostasis; complement activation, classical pathway; leukocyte migration during inflammatory response

0.5 mg (E-Coli)

805 USD

0.05 mg (Baculovirus)

805

0.5 mg (Yeast)

1030

0.05 mg (Mammalian-Cell)

1030

1 mg (E-Coli)

1140