Recombinant Human Fibulin-1 (FBLN1) | MyBioSource MBS950840 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human Fibulin-1 (FBLN1)

catalog :

MBS950840

quantity :

0.5 mg (E-Coli)

price :

1475 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS950840

products type :

Recombinant Protein

products full name :

Recombinant Human Fibulin-1 (FBLN1)

products short name :

Fibulin-1 (FBLN1)

products name syn :

Fibulin-1; FIBL-1

other names :

fibulin-1 isoform C; Fibulin-1; fibulin-1; fibulin 1

products gene name :

FBLN1

products gene name syn :

FBLN1; PP213

other gene names :

FBLN1; FBLN1; FBLN; FIBL1; FIBL-1

uniprot entry name :

FBLN1_HUMAN

host :

E Coli or Yeast or Baculovirus or Mammalian Cell

sequence positions :

30-703

sequence length :

674

sequence :

D VLLEACCADG HRMATHQKDC SLPYATESKE CRMVQEQCCH SQLEELHCAT GISLANEQDR CATPHGDNAS LEATFVKRCC HCCLLGRAAQ AQGQSCEYSL MVGYQCGQVF QACCVKSQET GDLDVGGLQE TDKIIEVEEE QEDPYLNDRC RGGGPCKQQC RDTGDEVVCS CFVGYQLLSD GVSCEDVNEC ITGSHSCRLG ESCINTVGSF RCQRDSSCGT GYELTEDNSC KDIDECESGI HNCLPDFICQ NTLGSFRCRP KLQCKSGFIQ DALGNCIDIN ECLSISAPCP IGHTCINTEG SYTCQKNVPN CGRGYHLNEE GTRCVDVDEC APPAEPCGKG HRCVNSPGSF RCECKTGYYF DGISRMCVDV NECQRYPGRL CGHKCENTLG SYLCSCSVGF RLSVDGRSCE DINECSSSPC SQECANVYGS YQCYCRRGYQ LSDVDGVTCE DIDECALPTG GHICSYRCIN IPGSFQCSCP SSGYRLAPNG RNCQDIDECV TGIHNCSINE TCFNIQGGFR CLAFECPENY RRSAATLQQE KTDTVRCIKS CRPNDVTCVF DPVHTISHTV ISLPTFREFT RPEEIIFLRA ITPPHPASQA NIIFDITEGN LRDSFDIIKR YMDGMTVGVV RQVRPIVGPF HAVLKLEMNY VVGGVVSHRN VVNVHIFVSE YWF

purity :

>90%

form :

Liquid containing glycerol; lyophilization may be available upon request.

storage stability :

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

other info1 :

Species: Homo sapiens (Human)

ncbi gi num :

34734062

ncbi acc num :

NP_001987.2

ncbi gb acc num :

NM_001996.3

uniprot acc num :

P23142

ncbi mol weight :

74,434 Da

ncbi pathways :

Elastic Fibre Formation Pathway (730310); Extracellular Matrix Organization Pathway (576262); Molecules Associated With Elastic Fibres Pathway (730311)

ncbi summary :

Fibulin 1 is a secreted glycoprotein that becomes incorporated into a fibrillar extracellular matrix. Calcium-binding is apparently required to mediate its binding to laminin and nidogen. It mediates platelet adhesion via binding fibrinogen. Four splice variants which differ in the 3' end have been identified. Each variant encodes a different isoform, but no functional distinctions have been identified among the four variants. [provided by RefSeq, Jul 2008]

uniprot summary :

FBLN1: Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes. Has been implicated in a role in cellular transformation and tumor invasion, it appears to be a tumor suppressor. May play a role in haemostasis and thrombosis owing to its ability to bind fibrinogen and incorporate into clots. Could play a significant role in modulating the neurotrophic activities of APP, particularly soluble APP. A chromosomal aberration involving FBLN1 is found in a complex type of synpolydactyly referred to as 3/3-prime/4 synpolydactyly associated with metacarpal and metatarsal synostoses. Reciprocal translocation t(12;22)(p11.2;q13.3) with C12orf2. Fibroblasts derived from a patient with synpolydactyly displayed alterations in the level of isoform D splice variant incorporated into the ECM and secreted into the conditioned culture medium. By contrast, the expression of isoform C was not perturbed in the patients fibroblasts. Furthermore, no aberrant polypeptides were detected in extracts of cultured patients fibroblasts. The translocation t(12;22) may result in haploinsufficiency of the isoform D splice variant, which could lead to the observed limb malformation. Elevated expression and altered processing of FBLN1 protein is associated with human breast cancer. Belongs to the fibulin family. 4 isoforms of the human protein are produced by alternative splicing. Protein type: Secreted, signal peptide; Extracellular matrix; Secreted. Chromosomal Location of Human Ortholog: 22q13.31. Cellular Component: extracellular matrix; proteinaceous extracellular matrix; extracellular space; extracellular region; basement membrane. Molecular Function: protease activator activity; extracellular matrix structural constituent; calcium ion binding. Biological Process: extracellular matrix organization and biogenesis; viral reproduction; embryo implantation. Disease: Synpolydactyly 2

size1 :

0.5 mg (E-Coli)

price1 :

1475 USD

size2 :

0.05 mg (Baculovirus)

price2 :

1475

size3 :

0.5 mg (Yeast)

price3 :

1705

size4 :

0.05 mg (Mammalian-Cell)

price4 :

1705

size5 :

1 mg (E-Coli)

price5 :

2515

more info or order :

MyBioSource product webpage