protein

Recombinant Macaca mulatta (Rhesus macaque) Tumor necrosis factor (TNF)

MBS950756

1 mg (E-Coli)

1320 USD

Recombinant Protein

Recombinant Macaca mulatta (Rhesus macaque) Tumor necrosis factor (TNF)

(Rhesus macaque) Tumor necrosis factor (TNF)

Recombinant (Rhesus macaque) Tumor necrosis factor (TNF); Tumor necrosis factor; Cachectin TNF-alpha Tumor necrosis factor ligand superfamily member 2; TNF-a Cleaved into the following 6 chains: 1. Tumor necrosis factor, membrane form; N-terminal fragment

tumor necrosis factor; Tumor necrosis factor; tumor necrosis factor; TNF-a; cachectin; tumor necrosis factor alpha; tumor necrosis factor (TNF superfamily, member 2); tumor necrosis factor ligand superfamily member 2; ATP-binding cassette, sub-family F (GCN20), member 1; Cachectin; TNF-alpha; Tumor necrosis factor ligand superfamily member 2; TNF-aCleaved into the following 6 chains:Tumor necrosis factor, membrane form; Alternative name(s):; N-terminal fragment

TNF; TNFA, TNFSF2

TNF; TNF; TNF-ALPHA; TNFA; TNFSF2; TNF-a; NTF; ICD1; ICD2

TNFA_MACMU

E Coli or Yeast or Baculovirus or Mammalian Cell

57-233

233

GPQREEFPKDPSLISPLAQAVRSSSRTPSDKPVAHVVAN
PQAEGQLQWLNRRANALLANGVELTDNQLVVPSEGLYLI
YSQVLFKGQGCPSNHVLLTHTISRIAVSYQTKVNLLSAI
KSPCQRETPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEI
NLPDYLDFAESGQVYFGIIAL

>90%

Liquid containing glycerol; lyophilization may be available upon request.

Store at -20 degree C. For extended storage, store at -20 or -80 degree C.

Species: Macaca mulatta (Rhesus macaque)

114051684

NP_001040614.1

NM_001047149.1

P48094

25,630 Da

Adipocytokine Signaling Pathway (86763); Adipocytokine Signaling Pathway (505); African Trypanosomiasis Pathway (194389); African Trypanosomiasis Pathway (194323); Allograft Rejection Pathway (86789); Allograft Rejection Pathway (535); Alzheimer's Disease Pathway (86767); Alzheimer's Disease Pathway (509); Amoebiasis Pathway (167336); Amoebiasis Pathway (167191)

Function: Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation.The TNF intracellular domain (ICD) form induces IL12 production in dendritic cells . By similarity. Subunit structure: Homotrimer. Interacts with SPPL2B . By similarity. Subcellular location: Cell membrane; Single-pass type II membrane protein . By similarity. Tumor necrosis factor, membrane form: Membrane; Single-pass type II membrane protein . By similarity. Tumor necrosis factor, soluble form: Secreted . By similarity. C-domain 1: Secreted . By similarity. C-domain 2: Secreted . By similarity. Post-translational modification: The soluble form derives from the membrane form by proteolytic processing. The membrane-bound form is further proteolytically processed by SPPL2A or SPPL2B through regulated intramembrane proteolysis producing TNF intracellular domains (ICD1 and ICD2) released in the cytosol and TNF C-domain 1 and C-domain 2 secreted into the extracellular space . By similarity.The membrane form, but not the soluble form, is phosphorylated on serine residues. Dephosphorylation of the membrane form occurs by binding to soluble TNFRSF1A/TNFR1 . By similarity.O-glycosylated; glycans contain galactose, N-acetylgalactosamine and N-acetylneuraminic acid . By similarity. Sequence similarities: Belongs to the tumor necrosis factor family.

1 mg (E-Coli)

1320 USD

1 mg (Yeast)

1780