Recombinant Human Polypyrimidine tract-binding protein 1 (PTBP1) | MyBioSource MBS950746 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human Polypyrimidine tract-binding protein 1 (PTBP1)

catalog :

MBS950746

quantity :

0.01 mg (Mammalian-Cell)

price :

315 USD

more info or order :

MyBioSource product webpage

image

image 1 :

product information

catalog number :

MBS950746

products type :

Recombinant Protein

products full name :

Recombinant Human Polypyrimidine tract-binding protein 1 (PTBP1)

products short name :

[Polypyrimidine tract-binding protein 1 (PTBP1)]

other names :

[polypyrimidine tract-binding protein 1 isoform a; Polypyrimidine tract-binding protein 1; polypyrimidine tract-binding protein 1; polypyrimidine tract binding protein 1; 57 kDa RNA-binding protein PPTB-1; Heterogeneous nuclear ribonucleoprotein I; hnRNP I]

products gene name :

[PTBP1]

other gene names :

[PTBP1; PTBP1; PTB; PTB2; PTB3; PTB4; pPTB; HNRPI; PTB-1; PTB-T; HNRNPI; HNRNP-I; PTB; PTB; hnRNP I]

host :

E Coli or Yeast or Baculovirus or Mammalian Cell

sequence positions :

[1-557. Full length of Isoform 3]

sequence length :

557

sequence :

MDGIVPDIAVGTKRGSDELFSTCVTNGPFIMSSNSASAA
NGNDSKKFKGDSRSAGVPSRVIHIRKLPIDVTEGEVISL
GLPFGKVTNLLMLKGKNQAFIEMNTEEAANTMVNYYTSV
TPVLRGQPIYIQFSNHKELKTDSSPNQARAQAALQAVNS
VQSGNLALAASAAAVDAGMAMAGQSPVLRIIVENLFYPV
TLDVLHQIFSKFGTVLKIITFTKNNQFQALLQYADPVSA
QHAKLSLDGQNIYNACCTLRIDFSKLTSLNVKYNNDKSR
DYTRPDLPSGDSQPSLDQTMAAAFGAPGIISASPYAGAG
FPPTFAIPQAAGLSVPNVHGALAPLAIPSAAAAAAAAGR
IAIPGLAGAGNSVLLVSNLNPERVTPQSLFILFGVYGDV
QRVKILFNKKENALVQMADGNQAQLAMSHLNGHKLHGKP
IRITLSKHQNVQLPREGQEDQGLTKDYGNSPLHRFKKPG
SKNFQNIFPPSATLHLSNIPPSVSEEDLKVLFSSNGGVV
KGFKFFQKDRKMALIQMGSVEEAVQALIDLHNHDLGENH
HLRVSFSKSTI

purity :

>85% (SDS-PAGE)

form :

Liquid containing glycerol

storage stability :

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

image1 heading :

SDS-Page

other info1 :

Species: Human

other info2 :

Storage Buffer: Tris-based buffer, 50% glycerol

products description :

This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA-binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. This protein has four repeats of quasi-RNA recognition motif (RRM) domains that bind RNAs. This protein binds to the intronic polypyrimidine tracts that requires pre-mRNA splicing and acts via the protein degradation ubiquitin-proteasome pathway. It may also promote the binding of U2 snRNP to pre-mRNAs. This protein is localized in the nucleoplasm and it is also detected in the perinucleolar structure. Alternatively spliced transcript variants encoding different isoforms have been described.

ncbi gi num :

4506243

ncbi acc num :

NP_002810.1

ncbi gb acc num :

NM_002819.4

uniprot acc num :

P26599

ncbi mol weight :

59,633 Da

ncbi pathways :

Gene Expression Pathway (105937); Processing Of Capped Intron-Containing Pre-mRNA Pathway (160950); MRNA Splicing Pathway (105951); MRNA Splicing - Major Pathway (105952); MRNA Processing Pathway (198843)

ncbi summary :

This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA-binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has four repeats of quasi-RNA recognition motif (RRM) domains that bind RNAs. This protein binds to the intronic polypyrimidine tracts that requires pre-mRNA splicing and acts via the protein degradation ubiquitin-proteasome pathway. It may also promote the binding of U2 snRNP to pre-mRNAs. This protein is localized in the nucleoplasm and it is also detected in the perinucleolar structure. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

uniprot summary :

Plays a role in pre-mRNA splicing and in the regulation of alternative splicing events. Activates exon skipping of its own pre-mRNA during muscle cell differentiation. Binds to the polypyrimidine tract of introns. May promote RNA looping when bound to two separate polypyrimidine tracts in the same pre-mRNA. May promote the binding of U2 snRNP to pre-mRNA. Cooperates with RAVER1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA. Represses the splicing of MAPT/Tau exon 10 (PubMed:15009664). In case of infection by picornaviruses, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation (PubMed:21518806).

size1 :

0.01 mg (Mammalian-Cell)

price1 :

315 USD

size2 :

0.02 mg (Mammalian-Cell)

price2 :

485

size3 :

0.05 mg (Mammalian-Cell)

price3 :

940

size4 :

0.1 mg (Mammalian-Cell)

price4 :

1300

more info or order :

MyBioSource product webpage