protein

Recombinant Human Potassium voltage-gated channel subfamily A member 2 (KCNA2)

MBS950643

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Recombinant Protein

Recombinant Human Potassium voltage-gated channel subfamily A member 2 (KCNA2)

Potassium voltage-gated channel subfamily A member 2 (KCNA2)

Recombinant Potassium voltage-gated channel subfamily A member 2 (KCNA2); Potassium voltage-gated channel subfamily A member 2; NGK1 Voltage-gated K(+) channel HuKIV Voltage-gated potassium channel HBK5 Voltage-gated potassium channel subunit Kv1.2

potassium voltage-gated channel subfamily A member 2 isoform b; Potassium voltage-gated channel subfamily A member 2; potassium voltage-gated channel subfamily A member 2; voltage-gated K(+) channel HuKIV; voltage-gated potassium channel HBK5; voltage-gated potassium channel protein Kv1.2; voltage-gated potassium channel subunit Kv1.2; potassium voltage-gated channel, shaker-related subfamily, member 2; NGK1; Voltage-gated K(+) channel HuKIV; Voltage-gated potassium channel HBK5; Voltage-gated potassium channel subunit Kv1.2

KCNA2

KCNA2; KCNA2; HK4; MK2; HBK5; NGK1; RBK2; HUKIV; KV1.2

KCNA2_HUMAN

E Coli or Yeast or Baculovirus or Mammalian Cell

1-163

>90%

Liquid containing glycerol; lyophilization may be available upon request.

Store at -20 degree C. For extended storage, store at -20 or -80 degree C.

Species: Homo sapiens (Human)

324022755

NP_001191198.1

NM_001204269.1

P16389

56,717 Da

Neuronal System Pathway (106513); Potassium Channels Pathway (366221); Voltage Gated Potassium Channels Pathway (366230)

Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, members of which allow nerve cells to efficiently repolarize following an action potential. The coding region of this gene is intronless, and the gene is clustered with genes KCNA3 and KCNA10 on chromosome 1. [provided by RefSeq, Jul 2008]

Kv1.2: Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.2/KCNA2 sub-subfamily. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, multi-pass; Membrane protein, integral; Channel, potassium. Chromosomal Location of Human Ortholog: 1p13. Cellular Component: presynaptic membrane; endoplasmic reticulum membrane; voltage-gated potassium channel complex; integral to plasma membrane; axon; lamellipodium; dendrite; integral to membrane; plasma membrane; perikaryon; nerve terminal; cell junction. Molecular Function: voltage-gated potassium channel activity; potassium channel activity; delayed rectifier potassium channel activity; outward rectifier potassium channel activity. Biological Process: synaptic transmission; optic nerve structural organization; generation of action potential; sensory perception of pain; regulation of dopamine secretion; protein homooligomerization; potassium ion transport. Disease: Epileptic Encephalopathy, Early Infantile, 32

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