protein

Recombinant Human Lactase-phlorizin hydrolase (LCT), partial

MBS950533

0.5 mg (E-Coli)

950 USD

Recombinant Protein

Recombinant Human Lactase-phlorizin hydrolase (LCT), partial

Lactase-phlorizin hydrolase (LCT), partial

Lactase-phlorizin hydrolase; Lactase-glycosylceramidase; Including the following 2 domains:; Lactase; EC=3.2.1.108; Phlorizin hydrolase; EC=3.2.1.62

lactase-phlorizin hydrolase preproprotein; Lactase-phlorizin hydrolase; lactase-phlorizin hydrolase; lactase-glycosylceramidase; lactase-phlorizin hydrolase-1; lactase; Lactase-glycosylceramidaseIncluding the following 2 domains:Lactase (EC:3.2.1.108); Phlorizin hydrolase (EC:3.2.1.62)

LCT

LCT; LPH

LCT; LCT; LAC; LPH; LPH1; LPH

LPH_HUMAN

E Coli or Yeast or Baculovirus or Mammalian Cell

>90%

Liquid containing glycerol; lyophilization may be available upon request.

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Species: Homo sapiens (Human)

32481206

NP_002290.2

NM_002299.2

P09848

218,587 Da

Carbohydrate Digestion And Absorption Pathway (170720); Carbohydrate Digestion And Absorption Pathway (170654); Digestion Of Dietary Carbohydrate Pathway (106197); Disease Pathway (530764); Galactose Metabolism Pathway (82931); Galactose Metabolism Pathway (292); Glycogen Storage Diseases Pathway (980468); Metabolic Pathways (132956); Metabolism Pathway (477135); Metabolism Of Carbohydrates Pathway (106196)

The protein encoded by this gene belongs to the family 1 of glycosyl hydrolases. The protein is integral to plasma membrane and has both phlorizin hydrolase activity and lactase activity. [provided by RefSeq, Jul 2008]

LCT: LPH splits lactose in the small intestine. Defects in LCT are the cause of congenital lactase deficiency (COLACD); also known as hereditary alactasia or disaccharide intolerance II. Congenital lactase deficiency is a an autosomal recessive, rare and severe gastrointestinal disorder. It is characterized by watery diarrhea in infants fed with breast milk or other lactose-containing formulas. An almost total lack of LCT activity is found in jejunal biopsy material of patients with congenital lactase deficiency. Opposite to congenital lactase deficiency, adult-type hypolactasia, also known as lactose intolerance, is the most common enzyme deficiency worldwide. It is caused by developmental down-regulation of lactase activity during childhood or early adulthood. The decline of lactase activity is a normal physiological phenomenon; however, the majority of Northern Europeans have the ability to maintain lactase activity and digest lactose throughout life (lactase persistence). The down-regulation of lactase activity operates at the transcriptional level and it is associated with a noncoding variation in the MCM6 gene, located in the upstream vicinity of LCT. Belongs to the glycosyl hydrolase 1 family. Protein type: EC 3.2.1.108; EC 3.2.1.62; Hydrolase; Membrane protein, integral; Carbohydrate Metabolism - galactose. Chromosomal Location of Human Ortholog: 2q21. Cellular Component: membrane; integral to plasma membrane; apical plasma membrane; plasma membrane. Molecular Function: lactase activity; glycosylceramidase activity. Biological Process: polysaccharide digestion; carbohydrate metabolic process; pathogenesis. Disease: Lactase Deficiency, Congenital

0.5 mg (E-Coli)

950 USD

0.05 mg (Baculovirus)

950

0.05 mg (Mammalian-Cell)

1175

0.5 mg (Yeast)

1175

1 mg (E-Coli)

1405