product summary
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company name :
MyBioSource
product type :
protein
product name :
Recombinant Rat Acetyl-CoA carboxylase 1
catalog :
MBS950263
quantity :
0.01 mg (Yeast)
price :
135 USD
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS950263
products type :
Recombinant Protein
products full name :
Recombinant Rat Acetyl-CoA carboxylase 1
products short name :
Acetyl-CoA carboxylase 1
products name syn :
ACC-alpha
other names :
Acetyl-CoA carboxylase 1; acetyl-CoA carboxylase 1; acetyl-CoA carboxylase alpha; ACC-alphaIncluding the following 1 domains:Biotin carboxylase (EC:6.3.4.14)
products gene name :
Acaca
other gene names :
Acaca; Acaca; ACC1; Acac; Acac; ACC1
uniprot entry name :
ACACA_RAT
host :
E Coli or Yeast or Baculovirus or Mammalian Cell
sequence positions :
116-617
sequence length :
2,337
sequence :
VIEKVLIANNGIAAVKCMRSIRRWSYEMFRNERAIRFVV
MVTPEDLKANAEYIKMADHYVPVPGGANNNNYANVELIL
DIAKRIPVQAVWAGWGHASENPKLPELLLKNGIAFMGPP
SQAMWALGDKIASSIVAQTAGIPTLPWSGSGLRVDWQEN
DFSKRILNVPQDLYEKGYVKDVDDGLKAAEEVGYPVMIK
ASEGGGGKGIRKVNNADDFPNLFRQVQAEVPGSPIFVMR
LAKQSRHLEVQILADQYGNAISLFGRDCSVQRRHQKIIE
EAPAAIATPAVFEHMEQCAVKLAKMVGYVSAGTVEYLYS
QDGSFYFLELNPRLQVEHPCTEMVADVNLPAAQLQIAMG
IPLFRIKDIRMMYGVSPWGDAPIDFENSAHVPCPRGHVI
AARITSENPDEGFKPSSGTVQELNFRSNKNVWGYFSVAA
AGGLHEFADSQFGHCFSWGENREEAISNMVVALKELSIR
GDFRTTVEYLIKLLETESFQLNRIDTGWLDRLIA
purity :
Greater than 90% as determined by SDS-PAGE.
form :
Liquid containing glycerol; lyophilization may be available upon request.
storage stability :
Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
other info2 :
Species: Rat
products categories :
Cancer
products description :
Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase.
products references :
Structure of the coding sequence and primary amino acid sequence of acetyl-coenzyme A carboxylase." Lopez-Casillas F., Bai D.-H., Luo X., Kong I.-S., Hermodson M.A., Kim K.-H. Proc. Natl. Acad. Sci. U.S.A. 85:5784-5788(1988)
ncbi acc num :
NP_071529.1
uniprot acc num :
P11497
ncbi mol weight :
59.84kD
ncbi pathways :
AMPK Signaling Pathway (989832); AMPK Signaling Pathway (992181); Fatty Acid Biosynthesis Pathway (198539); Fatty Acid Biosynthesis Pathway (83326); Fatty Acid Biosynthesis Pathway (294); Fatty Acid Biosynthesis, Initiation Pathway (880803); Fatty Acid Biosynthesis, Initiation Pathway (468275); Fatty Acid Metabolism Pathway (869319); Fatty Acid Metabolism Pathway (878045); Glucagon Signaling Pathway (1146235)
ncbi summary :
catalyzes the rate-limiting carboxylation of acetyl CoA to malonyl CoA during long-chain fatty acid synthesis [RGD, Feb 2006]
uniprot summary :
ACC1: a subunit of acetyl-CoA carboxylase (ACC), a multifunctional enzyme system. Catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. Phosphorylation by AMPK or PKA inhibits the enzymatic activity of ACC. ACC-alpha is the predominant isoform in liver, adipocyte and mammary gland. ACC-beta is the major isoform in skeletal muscle and heart. Phosphorylation regulates its activity. Protein type: Lipid Metabolism - fatty acid biosynthesis; Ligase; EC 6.4.1.2; EC 6.3.4.14; Carbohydrate Metabolism - pyruvate; Carbohydrate Metabolism - propanoate. Cellular Component: actin cytoskeleton; cytoplasm; cytosol; mitochondrion; nucleolus. Molecular Function: acetyl-CoA carboxylase activity; ATP binding; biotin binding; biotin carboxylase activity; kinase binding; metal ion binding. Biological Process: acetyl-CoA metabolic process; fatty acid biosynthetic process; lipid homeostasis; lipid metabolic process; multicellular organismal protein metabolic process; protein homotetramerization; response to drug; response to organic cyclic substance; tissue homeostasis
size1 :
0.01 mg (Yeast)
price1 :
135 USD
size2 :
0.01 mg (E-Coli)
price2 :
135
size3 :
0.05 mg (Yeast)
price3 :
255
size4 :
0.05 mg (E-Coli)
price4 :
255
size5 :
0.2 mg (Yeast)
price5 :
665
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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