ELISA/assay

NRF1 TFact DNA-Binding ELISA Kit

MBS9502225

96-Strip-Wells

550 USD

ELISA Kit

NRF1 TFact DNA-Binding ELISA Kit

[NRF1]

[Nuclear respiratory factor 1; NRF-1; Alpha palindromic-binding protein; Alpha-pal; NRF1]

[nuclear respiratory factor 1 isoform 1; Nuclear respiratory factor 1; nuclear respiratory factor 1; nuclear respiratory factor 1; Alpha palindromic-binding protein; Alpha-pal]

[NRF1]

[NRF1; NRF1; ALPHA-PAL; NRF-1; Alpha-pal]

Human

503

12 x 8-Well Microstrips

Store at 4 degree C for 6 months.

Testing Data

Samples: Tissue, Cultured Cells, Bacteria And Other Samples

Principle of the Assay: The Reduced Cytochrome C has a characteristic absorption peak at 550 nm. Mitochondrial Complex IVcan catalyze the Reduced Cytochrome C to produce Oxidized Cytochrome C, so t he activity of Comple IV can be calculated by detecting the decreasingrate of absorbance at 550 nm.

93141039

NP_001035199.1

NM_001040110.1

Q16656

55,674 Da

Energy Metabolism Pathway (198907); Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway (160977); Huntington's Disease Pathway (83100); Huntington's Disease Pathway (512); Metabolism Pathway (477135); Metabolism Of Lipids And Lipoproteins Pathway (160976); Mitochondrial Gene Expression Pathway (198757); PPARA Activates Gene Expression Pathway (530749); Regulation Of Lipid Metabolism By Peroxisome Proliferator-activated Receptor Alpha (PPARalpha) Pathway (119544)

This gene encodes a protein that homodimerizes and functions as a transcription factor which activates the expression of some key metabolic genes regulating cellular growth and nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication. The protein has also been associated with the regulation of neurite outgrowth. Alternative splicing results in multiple transcript variants. Confusion has occurred in bibliographic databases due to the shared symbol of NRF1 for this gene and for "nuclear factor (erythroid-derived 2)-like 1" which has an official symbol of NFE2L1. [provided by RefSeq, May 2014]

NRF1: Transcription factor that activates the expression of the EIF2S1 (EIF2-alpha) gene. Links the transcriptional modulation of key metabolic genes to cellular growth and development. Implicated in the control of nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication. Belongs to the NRF1/Ewg family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: DNA-binding; Transcription factor. Chromosomal Location of Human Ortholog: 7q32.2. Cellular Component: cytosol; nucleoplasm; nucleus. Molecular Function: oxidoreductase activity; protein binding; protein homodimerization activity. Biological Process: generation of precursor metabolites and energy; mitochondrion organization; positive regulation of transcription from RNA polymerase II promoter; regulation of transcription from RNA polymerase II promoter; transcription from RNA polymerase II promoter

96-Strip-Wells

550 USD