catalog number :
MBS949899
products type :
Recombinant Protein
products full name :
Recombinant Human Transcobalamin-1
products short name :
Transcobalamin-1
other names :
transcobalamin-1; Transcobalamin-1; transcobalamin-1; transcobalamin 1; Haptocorrin; HC; Protein R; Transcobalamin I; TC I; TCI
products gene name :
TCN1
other gene names :
TCN1; TCN1; HC; TC1; TCI; TC-1; TC1; TC-1; HC; TC I; TCI
uniprot entry name :
TCO1_HUMAN
host :
E Coli or Yeast or Baculovirus or Mammalian Cell
sequence positions :
24 – 433, Mature full length protein.
sequence :
EICEVSEENYIRLKPLLNTMIQSNYNRGTSAVNVVLSLK
LVGIQIQTLMQKMIQQIKYNVKSRLSDVSSGELALIILA
LGVCRNAEENLIYDYHLIDKLENKFQAEIENMEAHNGTP
LTNYYQLSLDVLALCLFNGNYSTAEVVNHFTPENKNYYF
GSQFSVDTGAMAVLALTCVKKSLINGQIKADEGSLKNIS
IYTKSLVEKILSEKKENGLIGNTFSTGEAMQALFVSSDY
YNENDWNCQQTLNTVLTEISQGAFSNPNAAAQVLPALMG
KTFLDINKDSSCVSASGNFNISADEPITVTPPDSQSYIS
VNYSVRINETYFTNVTVLNGSVFLSVMEKAQKMNDTIFG
FTMEERSWGPYITCIQGLCANNNDRTYWELLSGGEPLSQ
GAGSYVVRNGENLEVRWSKY
purity :
Greater than 90% as determined by SDS-PAGE.
form :
Liquid containing glycerol; lyophilization may be available upon request.
storage stability :
Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
products categories :
Signal Transduction
ncbi acc num :
NP_001053.2
ncbi gb acc num :
NM_001062.3
ncbi mol weight :
61.57kD
ncbi pathways :
Cobalamin (Cbl, Vitamin B12) Transport And Metabolism Pathway (1270152); Metabolism Pathway (1269956); Metabolism Of Vitamins And Cofactors Pathway (1270144); Metabolism Of Water-soluble Vitamins And Cofactors Pathway (1270145); Vitamin B12 Metabolism Pathway (920974)
ncbi summary :
This gene encodes a member of the vitamin B12-binding protein family. This family of proteins, alternatively referred to as R binders, is expressed in various tissues and secretions. This protein is a major constituent of secondary granules in neutrophils and facilitates the transport of cobalamin into cells. [provided by RefSeq, Jul 2008]
uniprot summary :
TCN1: Vitamin B12-binding protein. Transports cobalamin into cells. Belongs to the eukaryotic cobalamin transport proteins family. Protein type: Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 11q11-q12. Cellular Component: extracellular region; extracellular space. Molecular Function: cobalamin binding. Biological Process: cobalamin metabolic process; cobalamin transport; cobalt ion transport; vitamin metabolic process; water-soluble vitamin metabolic process