catalog number :
MBS949651
products type :
Recombinant Protein
products full name :
Recombinant Mouse Metalloproteinase inhibitor 3 (Timp3)
products short name :
Metalloproteinase inhibitor 3 (Timp3)
products name syn :
Metalloproteinase inhibitor 3; Tissue inhibitor of metalloproteinases 3; TIMP-3
other names :
metalloproteinase inhibitor 3; Metalloproteinase inhibitor 3; metalloproteinase inhibitor 3; tissue inhibitor of metalloproteinases 3; tissue inhibitor of metalloproteinase 3; Tissue inhibitor of metalloproteinases 3; TIMP-3
products gene name :
Timp3
products gene name syn :
Timp3; Sun; Timp-3
other gene names :
Timp3; Timp3; Timp-3; Sun; Timp-3; TIMP-3
uniprot entry name :
TIMP3_MOUSE
host :
E Coli or Yeast or Baculovirus or Mammalian Cell
sequence positions :
24-211
sequence :
CTCSPSH PQDAFCNSDI VIRAKVVGKK LVKEGPFGTL VYTIKQMKMY RGFSKMPHVQ YIHTEASESL CGLKLEVNKY QYLLTGRVYE GKMYTGLCNF VERWDHLTLS QRKGLNYRYH LGCNCKIKSC YYLPCFVTSK NECLWTDMLS NFGYPGYQSK HYACIRQKGG YCSWYRGWAP PDKSISNATD P
form :
Liquid containing glycerol; lyophilization may be available upon request.
storage stability :
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
other info1 :
Species: Mus musculus (Mouse)
products description :
Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli.
ncbi acc num :
NP_035725.1
ncbi gb acc num :
NM_011595.2
ncbi mol weight :
24,182 Da
ncbi pathways :
Endochondral Ossification Pathway (198336); Matrix Metalloproteinases Pathway (198370); MicroRNAs In Cancer Pathway (852715); MicroRNAs In Cancer Pathway (852928); Proteoglycans In Cancer Pathway (782024); Proteoglycans In Cancer Pathway (782054)
uniprot summary :
TIMP3: Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, MMP-13, MMP-14 and MMP-15. Interacts with EFEMP1. Belongs to the protease inhibitor I35 (TIMP) family. Protein type: Secreted; Motility/polarity/chemotaxis; Secreted, signal peptide. Cellular Component: extracellular matrix; extracellular space; proteinaceous extracellular matrix; cytoplasm; extracellular region; basement membrane; nucleus. Molecular Function: metalloendopeptidase inhibitor activity; enzyme inhibitor activity; protease binding; protease inhibitor activity; metal ion binding. Biological Process: negative regulation of proteolysis; negative regulation of metalloenzyme activity; response to cytokine stimulus; response to hormone stimulus; negative regulation of peptidase activity; negative regulation of membrane protein ectodomain proteolysis
size2 :
0.05 mg (Baculovirus)
size4 :
0.05 mg (Mammalian-Cell)