catalog number :
MBS949386
products type :
Recombinant Protein
products full name :
Recombinant Rat Apolipoprotein C-III
products short name :
Apolipoprotein C-III
products name syn :
Apolipoprotein C3
other names :
Apolipoprotein C-III; Apolipoprotein C-III; Apolipoprotein C3
products gene name :
Apoc3
other gene names :
Apoc3; Apo-CIII; ApoC-III
uniprot entry name :
APOC3_RAT
host :
E Coli or Yeast or Baculovirus or Mammalian Cell
sequence positions :
21-101
sequence :
DEGEGSLLLGSMQGYMEQASKTVQDALSSMQESDIAVVA
SRGWMDNRFKSLKGYWSKFTDKFTGLWESGPEDQLTTPT
LEP
purity :
Greater than 90% as determined by SDS-PAGE.
form :
Liquid containing glycerol; lyophilization may be available upon request.
storage stability :
Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
products description :
Component of triglyceride-rich very low density lipoproteins (VLDL) and high density lipoproteins (HDL) in plasma. Plays a multifaceted role in triglyceride homeostasis. Intracellularly, promotes hepatic very low density lipoprotein 1 (VLDL1) assembly and secretion; extracellularly, attenuates hydrolysis and clearance of triglyceride-rich lipoproteins (TRLs). Impairs the lipolysis of TRLs by inhibiting lipoprotein lipase and the hepatic uptake of TRLs by remnant receptors.
products references :
Linkage, evolution, and expression of the rat apolipoprotein A-I, C-III, and A-IV genes.Haddad I.A., Ordovas J.M., Fitzpatrick T., Karathanasis S.K.J. Biol. Chem. 261:13268-13277(1986)
Haddad I.A., Ordovas J.M., Fitzpatrick T., Karathanasis S.K.
ncbi pathways :
Chylomicron-mediated Lipid Transport Pathway (1333315); HDL-mediated Lipid Transport Pathway (1333316); Lipid Digestion, Mobilization, And Transport Pathway (1333311); Lipoprotein Metabolism Pathway (1333314); Metabolism Pathway (1333271); Metabolism Of Fat-soluble Vitamins Pathway (1333460); Metabolism Of Lipids And Lipoproteins Pathway (1333310); Metabolism Of Vitamins And Cofactors Pathway (1333446); PPAR Signaling Pathway (83434); PPAR Signaling Pathway (450)
uniprot summary :
APOC3: Component of triglyceride-rich very low density lipoproteins (VLDL) and high density lipoproteins (HDL) in plasma. Plays a multifaceted role in triglyceride homeostasis. Intracellularly, promotes hepatic very low density lipoprotein 1 (VLDL1) assembly and secretion; extracellularly, attenuates hydrolysis and clearance of triglyceride-rich lipoproteins (TRLs). Impairs the lipolysis of TRLs by inhibiting lipoprotein lipase and the hepatic uptake of TRLs by remnant receptors. Protein type: Secreted, signal peptide; Lipid-binding; Secreted. Cellular Component: cell; chylomicron; extracellular space. Molecular Function: enzyme regulator activity; lipase inhibitor activity; lipid transporter activity; phospholipid binding. Biological Process: cholesterol efflux; cholesterol homeostasis; cholesterol metabolic process; G-protein coupled receptor protein signaling pathway; inflammatory response; lipid catabolic process; lipid transport; lipoprotein metabolic process; lipoprotein transport; negative regulation of fatty acid biosynthetic process; negative regulation of lipid catabolic process; negative regulation of lipid metabolic process; negative regulation of lipoprotein lipase activity; negative regulation of receptor-mediated endocytosis; phospholipid efflux; regulation of Cdc42 protein signal transduction; response to drug; response to nutrient; response to peptide hormone stimulus; response to triglyceride; response to vitamin A; triacylglycerol catabolic process; triacylglycerol metabolic process; triacylglycerol mobilization
size4 :
0.05 mg (Baculovirus)
size5 :
0.05 mg (Mammalian-Cell)