protein

Recombinant Human Hepcidin (HAMP)

MBS949194

1 mg (E Coli Derived

1375 USD

Recombinant Protein

Recombinant Human Hepcidin (HAMP)

Hepcidin (HAMP)

Recombinant Hepcidin (HAMP); Hepcidin; Liver-expressed antimicrobial peptide 1; LEAP-1 Putative liver tumor regressor; PLTR Cleaved into the following 2 chains: 1. Hepcidin-25; 2. Hepc25 3. Hepcidin-20; 4. Hepc20

hepcidin preproprotein; Hepcidin; hepcidin; putative liver tumor regressor; liver-expressed antimicrobial peptide 1; hepcidin antimicrobial peptide; Liver-expressed antimicrobial peptide 1; LEAP-1; Putative liver tumor regressor

HAMP; HEPC, LEAP1; UNQ487/PRO1003

HAMP; HAMP; HEPC; PLTR; HFE2B; LEAP1; HEPC; LEAP1; LEAP-1; PLTR; Hepc25; Hepc20

HEPC_HUMAN

E Coli or Yeast

>90%

This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.

Store at -20 degree C. For extended storage, store at -20 or -80 degree C.

Tag Information: His tagged (Host tag may vary. Please inquire for specific tag information). Species: Homo sapiens (Human)

Storage Buffer: PBS pH 7.4, 50% glycerol

10863973

NP_066998.1

NM_021175.2

P81172

9,408 Da

The product encoded by this gene is involved in the maintenance of iron homeostasis, and it is necessary for the regulation of iron storage in macrophages, and for intestinal iron absorption. The preproprotein is post-translationally cleaved into mature peptides of 20, 22 and 25 amino acids, and these active peptides are rich in cysteines, which form intramolecular bonds that stabilize their beta-sheet structures. These peptides exhibit antimicrobial activity. Mutations in this gene cause hemochromatosis type 2B, also known as juvenile hemochromatosis, a disease caused by severe iron overload that results in cardiomyopathy, cirrhosis, and endocrine failure. [provided by RefSeq, Jul 2008]

Function: Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages . By similarity. Ref.2Has strong antimicrobial activity against E.coli ML35P N.cinerea and weaker against S.epidermidis, S.aureus and group b streptococcus bacteria. Active against the fungus C.albicans. No activity against P.aeruginosa. Ref.2. Subcellular location: Secreted. Tissue specificity: Highest expression in liver and to a lesser extent in heart and brain. Low levels in lung, tonsils, salivary gland, trachea, prostate gland, adrenal gland and thyroid gland. Secreted into the urine. Ref.2. Involvement in disease: Defects in HAMP are the cause of hemochromatosis type 2B (HFE2B) [. MIM:613313]; also known as juvenile hemochromatosis (JH). HFE2B is a disorder of iron metabolism with excess deposition of iron in the tissues, bronze skin pigmentation, hepatic cirrhosis, arthropathy and diabetes. The most common symptoms of hemochromatosis type 2 at presentation are hypogonadism and cardiomyopathy. Ref.11 Ref.12 Ref.13 Ref.14 Ref.15. Sequence similarities: Belongs to the hepcidin family. Mass spectrometry: Molecular mass is 2789.8 Da from positions 60 - 84. Determined by MALDI. Ref.2

1 mg (E Coli Derived)

1375 USD