catalog number :
MBS948976
products type :
Recombinant Protein
products full name :
Recombinant Human fMet-Leu-Phe receptor (FPR1), partial
products short name :
[fMet-Leu-Phe receptor (FPR1)]
other names :
[fMet-Leu-Phe receptor; fMet-Leu-Phe receptor; fMet-Leu-Phe receptor; formyl peptide receptor 1; N-formyl peptide receptor; FPR; N-formylpeptide chemoattractant receptor]
products gene name :
[FPR1]
other gene names :
[FPR1; FPR1; FPR; FMLP; fMLP receptor; FPR]
host :
E Coli or Yeast or Baculovirus or Mammalian Cell
sequence positions :
[306-350. Partial, provide the complete cytoplasmic domain at the C-terminal.]
sequence :
QDFRERLIHALPASLERALTEDSTQTSDTATNSTLPSAE
VELQAK
form :
Liquid containing glycerol
storage stability :
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
other info1 :
Species: Homo sapiens (Human)
other info2 :
Storage Buffer: Tris-based buffer, 50% glycerol
ncbi acc num :
NP_001180235.1
ncbi gb acc num :
NM_001193306.1
ncbi mol weight :
38,446 Da
ncbi pathways :
Class A/1 (Rhodopsin-like Receptors) Pathway (106357); Formyl Peptide Receptors Bind Formyl Peptides And Many Other Ligands Pathway (161021); G Alpha (i) Signalling Events Pathway (119550); GPCR Downstream Signaling Pathway (119548); GPCR Ligand Binding Pathway (161020); GPCRs, Class A Rhodopsin-like Pathway (198886); Neuroactive Ligand-receptor Interaction Pathway (83053); Neuroactive Ligand-receptor Interaction Pathway (462); Peptide GPCRs Pathway (198897); Peptide Ligand-binding Receptors Pathway (106358)
ncbi summary :
This gene encodes a G protein-coupled receptor of mammalian phagocytic cells that is a member of the G-protein coupled receptor 1 family. The protein mediates the response of phagocytic cells to invasion of the host by microorganisms and is important in host defense and inflammation.[provided by RefSeq, Jul 2010]
uniprot summary :
High affinity receptor for N-formyl-methionyl peptides (fMLP), which are powerful neutrophil chemotactic factors (PubMed:2161213, PubMed:2176894, PubMed:10514456, PubMed:15153520). Binding of fMLP to the receptor stimulates intracellular calcium mobilization and superoxide anion release (PubMed:2161213, PubMed:1712023, PubMed:15153520). This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system (PubMed:1712023, PubMed:10514456).
size5 :
0.05 mg (Baculovirus)
size9 :
0.1 mg (Baculovirus)
size10 :
0.05 mg (Mammalian-Cell)
size13 :
0.5 mg (Baculovirus)
size14 :
0.1 mg (Mammalian-Cell)
size16 :
1 mg (Baculovirus)