Recombinant Rat Huntingtin (Htt), partial | MyBioSource MBS948956 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Rat Huntingtin (Htt), partial

catalog :

MBS948956

quantity :

0.5 mg (E-Coli)

price :

930 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS948956

products type :

Recombinant Protein

products full name :

Recombinant Rat Huntingtin (Htt), partial

products short name :

Huntingtin (Htt), partial

products name syn :

Huntingtin; Huntington disease protein homolog; HD protein homolog

other names :

Huntingtin; Huntingtin; huntingtin; HD protein homolog; Huntington disease gene homolog; huntingtin (Huntington disease); huntington disease protein homolog; huntingtin; Huntington disease protein homolog; HD protein homolog

products gene name :

Htt

products gene name syn :

Htt; Hd; Hdh

other gene names :

Htt; Htt; Hd; Hdh; Hd; Hdh; HD protein homolog

uniprot entry name :

HD_RAT

host :

E Coli or Yeast or Baculovirus or Mammalian Cell

purity :

>90%

form :

Liquid containing glycerol; lyophilization may be available upon request.

storage stability :

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

other info1 :

Species: Rattus norvegicus (Rat)

ncbi gi num :

1708162

ncbi acc num :

P51111.1

uniprot acc num :

P51111

ncbi mol weight :

343,762 Da

ncbi pathways :

EGFR1 Signaling Pathway (198427); Huntington's Disease Pathway (83492); Huntington's Disease Pathway (512)

ncbi summary :

necessary for normal neuronal development; mutation of human homolog is associated with Huntingtons disease [RGD, Feb 2006]

uniprot summary :

Huntingtin: may play a role in microtubule-mediated transport or vesicle function. Widely expressed with the highest level of expression in the brain (nerve fibers, varicosities, and nerve endings). In the brain, the regions where it can be mainly found are the cerebellar cortex, the neocortex, the striatum, and the hippocampal formation. Defects are the cause of Huntington s disease, a neurodegenerative disorder characterized by loss of striatal neurons. This is thought to be caused by an expanded, unstable trinucleotide repeat in the Huntingtin gene, which translates as a polyglutamine repeat in the protein product. The Huntingtin locus is large, spanning 180 kb and consisting of 67 exons. The Huntingtin gene is widely expressed and is required for normal development. It is expressed as 2 alternatively polyadenylated isoforms displaying different relative abundance in various fetal and adult tissues. Protein type: Cytoskeletal. Cellular Component: Golgi apparatus; cytoplasmic vesicle membrane; protein complex; clathrin-coated vesicle; mitochondrion; endoplasmic reticulum; cell; postsynaptic density; cytoplasmic membrane-bound vesicle; dendrite; autophagic vacuole; inclusion body; cytosol; nucleoplasm; cell soma; axon; cytoplasm; late endosome; intracellular; nucleus. Molecular Function: identical protein binding; protein binding; p53 binding; dynein intermediate chain binding; beta-tubulin binding; diazepam binding; transcription factor binding; receptor binding. Biological Process: mRNA transport; central nervous system development; citrulline metabolic process; regulation of protein phosphatase type 2A activity; regulation of synaptic plasticity; gastrulation; determination of adult life span; endosome transport; mitochondrial transport; anterior/posterior pattern formation; L-glutamate import; regulation of mitochondrial membrane potential; protein import into nucleus; organ development; quinolinate biosynthetic process; negative regulation of neuron apoptosis; endoplasmic reticulum organization and biogenesis; mitochondrion organization and biogenesis; anatomical structure morphogenesis; cell aging; social behavior; peptide hormone secretion; lactate biosynthetic process from pyruvate; iron ion homeostasis; neurogenesis; insulin secretion; dopamine receptor signaling pathway; neuron development; regulation of mitochondrial membrane permeability; response to calcium ion; neural plate formation; negative regulation of apoptosis; ER to Golgi vesicle-mediated transport; apoptosis; paraxial mesoderm formation; locomotory behavior; learning and/or memory; establishment of mitotic spindle orientation; vesicle transport along microtubule; retrograde vesicle-mediated transport, Golgi to ER; visual learning; Golgi organization and biogenesis; associative learning; grooming behavior; positive regulation of inositol-1,4,5-triphosphate receptor activity; striatum development; axon cargo transport; olfactory lobe development; learning; neuron apoptosis; hormone metabolic process; spermatogenesis; brain development; urea cycle

size1 :

0.5 mg (E-Coli)

price1 :

930 USD

size2 :

0.05 mg (Baculovirus)

price2 :

930

size3 :

0.5 mg (Yeast)

price3 :

1155

size4 :

0.05 mg (Mammalian-Cell)

price4 :

1155

size5 :

1 mg (E-Coli)

price5 :

1370

more info or order :

MyBioSource product webpage