catalog number :
MBS948912
products type :
Recombinant Protein
products full name :
Recombinant Human Lymphocyte activation gene 3 protein (LAG3)
products short name :
Lymphocyte activation gene 3 protein (LAG3)
products name syn :
Lymphocyte activation gene 3 protein; LAG-3; Protein FDC; CD_antigen=; CD223
other names :
lymphocyte activation gene 3 protein; Lymphocyte activation gene 3 protein; lymphocyte activation gene 3 protein; lymphocyte-activation gene 3; Protein FDC; CD_antigen: CD223
products gene name :
LAG3
products gene name syn :
LAG3; FDC
other gene names :
LAG3; LAG3; CD223; FDC; LAG-3
uniprot entry name :
LAG3_HUMAN
host :
E Coli or Yeast or Baculovirus or Mammalian Cell
sequence positions :
29-450
sequence :
VP VVWAQEGAPA QLPCSPTIPL QDLSLLRRAG VTWQHQPDSG PPAAAPGHPL APGPHPAAPS SWGPRPRRYT VLSVGPGGLR SGRLPLQPRV QLDERGRQRG DFSLWLRPAR RADAGEYRAA VHLRDRALSC RLRLRLGQAS MTASPPGSLR ASDWVILNCS FSRPDRPASV HWFRNRGQGR VPVRESPHHH LAESFLFLPQ VSPMDSGPWG CILTYRDGFN VSIMYNLTVL GLEPPTPLTV YAGAGSRVGL PCRLPAGVGT RSFLTAKWTP PGGGPDLLVT GDNGDFTLRL EDVSQAQAGT YTCHIHLQEQ QLNATVTLAI ITVTPKSFGS PGSLGKLLCE VTPVSGQERF VWSSLDTPSQ RSFSGPWLEA QEAQLLSQPW QCQLYQGERL LGAAVYFTEL SSPGAQRSGR APGALPAGHL
form :
Liquid containing glycerol; lyophilization may be available upon request.
storage stability :
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
other info1 :
Species: Homo sapiens (Human)
products description :
Involved in lymphocyte activation. Binds to HLA class-II antigens.
ncbi acc num :
NP_002277.4
ncbi gb acc num :
NM_002286.5
ncbi mol weight :
57,449 Da
ncbi summary :
Lymphocyte-activation protein 3 belongs to Ig superfamily and contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. The sequence data, exon/intron organization, and chromosomal localization all indicate a close relationship of LAG3 to CD4. [provided by RefSeq, Jul 2008]
uniprot summary :
LAG3: Involved in lymphocyte activation. Binds to HLA class-II antigens. Protein type: Membrane protein, integral. Chromosomal Location of Human Ortholog: 12p13.32. Cellular Component: integral to membrane; external side of plasma membrane. Molecular Function: transmembrane receptor activity; antigen binding; MHC class II protein binding. Biological Process: cell surface receptor linked signal transduction; negative regulation of interleukin-2 biosynthetic process; positive regulation of natural killer cell mediated cytotoxicity; negative regulation of T cell activation