catalog number :
MBS948782
products type :
Recombinant Protein
products full name :
Recombinant Mouse Osteocalcin
products short name :
Osteocalcin
products name syn :
Bone Gla protein; BGP; Gamma-carboxyglutamic acid-containing protein
other names :
osteocalcin preproprotein; Osteocalcin; osteocalcin; bone gamma carboxyglutamate protein; Bone Gla protein; BGP; Gamma-carboxyglutamic acid-containing protein
products gene name :
Bglap
other gene names :
Bglap; Bglap; OC; BGP; OG1; mOC-A; Bglap1; BGP
uniprot entry name :
OSTCN_MOUSE
host :
E Coli or Yeast or Baculovirus or Mammalian Cell
sequence positions :
50-95
sequence :
YLGASVPSPDPLEPTREQCELNPACDELSDQYGLKTAYK
RIYGITI
purity :
Greater than 90% as determined by SDS-PAGE.
form :
Liquid containing glycerol; lyophilization may be available upon request.
storage stability :
Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
other info2 :
Species: Mus musculus (Mouse)
products categories :
Signal Transduction
products description :
Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium.
products references :
The mouse osteocalcin gene cluster contains three genes with two separate spatial and temporal patterns of expression."
Desbois C., Hogue D.A., Karsenty G.
J. Biol. Chem. 269:1183-1190(1994)
ncbi acc num :
NP_031567.1
ncbi gb acc num :
NM_007541.3
ncbi mol weight :
21.11kD
ncbi pathways :
Gamma Carboxylation, Hypusine Formation And Arylsulfatase Activation Pathway (1324159); Gamma-carboxylation Of Protein Precursors Pathway (1324161); Gamma-carboxylation, Transport, And Amino-terminal Cleavage Of Proteins Pathway (1324160); Metabolism Of Proteins Pathway (1324154); Post-translational Protein Modification Pathway (1324158); Removal Of Aminoterminal Propeptides From Gamma-carboxylated Proteins Pathway (1324163); Transport Of Gamma-carboxylated Protein Precursors From The Endoplasmic Reticulum To The Golgi Apparatus Pathway (1324162)
ncbi summary :
This gene encodes one of the most abundant non-collagenous proteins in bone tissue that is localized to the mineralized matrix of bone. The encoded preproprotein undergoes proteolytic processing and post-translational gamma carboxylation to generate a mature, calcium-binding protein. Mice lacking the encoded protein develop abnormalities of bone remodelling. This gene is located adjacent to two other osteocalcin-related genes on chromosome 3. [provided by RefSeq, Oct 2015]