Recombinant Human Endoplasmin (HSP90B1) | MyBioSource MBS947955 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human Endoplasmin (HSP90B1)

catalog :

MBS947955

quantity :

0.5 mg (E-Coli)

price :

1600 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS947955

products type :

Recombinant Protein

products full name :

Recombinant Human Endoplasmin (HSP90B1)

products short name :

Endoplasmin (HSP90B1)

products name syn :

Endoplasmin; 94 kDa glucose-regulated protein; GRP-94; Heat shock protein 90 kDa beta member 1; Tumor rejection antigen 1; gp96 homolog

other names :

endoplasmin; Endoplasmin; endoplasmin; tumor rejection antigen 1; epididymis luminal protein 35; 94 kDa glucose-regulated protein; tumor rejection antigen (gp96) 1; endothelial cell (HBMEC) glycoprotein; heat shock protein 90 kDa beta member 1; stress-inducible tumor rejection antigen gp96; epididymis secretory sperm binding protein Li 125m; heat shock protein 90kDa beta (Grp94), member 1; 94 kDa glucose-regulated protein; GRP-94; Heat shock protein 90 kDa beta member 1; Tumor rejection antigen 1; gp96 homolog

products gene name :

HSP90B1

products gene name syn :

HSP90B1; GRP94; TRA1

other gene names :

HSP90B1; HSP90B1; ECGP; GP96; TRA1; GRP94; HEL35; HEL-S-125m; GRP94; TRA1; GRP-94

uniprot entry name :

ENPL_HUMAN

host :

E Coli or Yeast or Baculovirus or Mammalian Cell

sequence positions :

22-803

sequence length :

782

sequence :

DDEVDVDGT VEEDLGKSRE GSRTDDEVVQ REEEAIQLDG LNASQIRELR EKSEKFAFQA EVNRMMKLII NSLYKNKEIF LRELISNASD ALDKIRLISL TDENALSGNE ELTVKIKCDK EKNLLHVTDT GVGMTREELV KNLGTIAKSG TSEFLNKMTE AQEDGQSTSE LIGQFGVGFY SAFLVADKVI VTSKHNNDTQ HIWESDSNEF SVIADPRGNT LGRGTTITLV LKEEASDYLE LDTIKNLVKK YSQFINFPIY VWSSKTETVE EPMEEEEAAK EEKEESDDEA AVEEEEEEKK PKTKKVEKTV WDWELMNDIK PIWQRPSKEV EEDEYKAFYK SFSKESDDPM AYIHFTAEGE VTFKSILFVP TSAPRGLFDE YGSKKSDYIK LYVRRVFITD DFHDMMPKYL NFVKGVVDSD DLPLNVSRET LQQHKLLKVI RKKLVRKTLD MIKKIADDKY NDTFWKEFGT NIKLGVIEDH SNRTRLAKLL RFQSSHHPTD ITSLDQYVER MKEKQDKIYF MAGSSRKEAE SSPFVERLLK KGYEVIYLTE PVDEYCIQAL PEFDGKRFQN VAKEGVKFDE SEKTKESREA VEKEFEPLLN WMKDKALKDK IEKAVVSQRL TESPCALVAS QYGWSGNMER IMKAQAYQTG KDISTNYYAS QKKTFEINPR HPLIRDMLRR IKEDEDDKTV LDLAVVLFET ATLRSGYLLP DTKAYGDRIE RMLRLSLNID PDAKVEEEPE EEPEETAEDT TEDTEQDEDE EMDVGTDEEE ETAKESTAEK DEL

purity :

>90%

form :

Liquid containing glycerol; lyophilization may be available upon request.

storage stability :

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

other info1 :

Species: Homo sapiens (Human)

products description :

HSP90B1; GRP94, TRA1

ncbi gi num :

4507677

ncbi acc num :

NP_003290.1

ncbi gb acc num :

NM_003299.2

uniprot acc num :

P14625

ncbi mol weight :

92,469 Da

ncbi pathways :

Activation Of Chaperone Genes By ATF6-alpha Pathway (530770); Activation Of Chaperones By ATF6-alpha Pathway (105905); Estrogen Signaling Pathway (799177); Estrogen Signaling Pathway (799197); IL6-mediated Signaling Events Pathway (137932); Immune System Pathway (106386); Innate Immune System Pathway (106387); Metabolism Of Proteins Pathway (106230); NOD-like Receptor Signaling Pathway (122191); NOD-like Receptor Signaling Pathway (122131)

ncbi summary :

This gene encodes a member of a family of adenosine triphosphate(ATP)-metabolizing molecular chaperones with roles in stabilizing and folding other proteins. The encoded protein is localized to melanosomes and the endoplasmic reticulum. Expression of this protein is associated with a variety of pathogenic states, including tumor formation. There is a microRNA gene located within the 5' exon of this gene. There are pseudogenes for this gene on chromosomes 1 and 15. [provided by RefSeq, Aug 2012]

uniprot summary :

GRP94: Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with CNPY3, required for proper folding of Toll-like receptors. Functions in endoplasmic reticulum associated degradation (ERAD). Has ATPase activity. Homodimer; disulfide-linked. Component of an EIF2 complex at least composed of CELF1/CUGBP1, CALR, CALR3, EIF2S1, EIF2S2, HSP90B1 and HSPA5. Part a large chaperone multiprotein complex comprising DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PDIA6, PPIB, SDF2L1, UGT1A1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX. Interacts with AIMP1; regulates its retention in the endoplasmic reticulum. Interacts with OS9. Interacts with CNPY3. This interaction is disrupted in the presence of ATP. Interacts with TLR4 and TLR9, but not with TLR3. Belongs to the heat shock protein 90 family. Protein type: Secreted; Secreted, signal peptide; Apoptosis; Heat shock protein. Chromosomal Location of Human Ortholog: 12q24.2-q24.3. Cellular Component: endoplasmic reticulum membrane; focal adhesion; endoplasmic reticulum lumen; endoplasmic reticulum; extracellular region; cytosol; extracellular matrix; membrane; perinuclear region of cytoplasm; melanosome; plasma membrane; midbody; nucleus. Molecular Function: protein binding; low-density lipoprotein receptor binding; RNA binding; unfolded protein binding; virion binding; calcium ion binding; protein phosphatase binding; ATP binding. Biological Process: actin rod formation; receptor-mediated endocytosis; ER-associated protein catabolic process; unfolded protein response; regulation of phosphoprotein phosphatase activity; protein transport; cellular protein metabolic process; unfolded protein response, activation of signaling protein activity; sequestering of calcium ion; toll-like receptor signaling pathway; response to hypoxia; innate immune response; negative regulation of apoptosis

size1 :

0.5 mg (E-Coli)

price1 :

1600 USD

size2 :

0.05 mg (Baculovirus)

price2 :

1600

size3 :

0.5 mg (Yeast)

price3 :

1830

size4 :

0.05 mg (Mammalian-Cell)

price4 :

1830

size5 :

1 mg (E-Coli)

price5 :

2745

more info or order :

MyBioSource product webpage