product summary
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company name :
MyBioSource
product type :
ELISA/assay
product name :
Human Gremlin-2, GREM2 ELISA Kit
catalog :
MBS946775
quantity :
48-Strip-Wells
price :
510 USD
more info or order :
product information
catalog number :
MBS946775
products type :
ELISA Kit
products full name :
Human Gremlin-2, GREM2 ELISA Kit
products short name :
gremlin 2, cysteine knot superfamily, homolog (Xenopus laevis)
products name syn :
Human Gremlin-2 (GREM2) ELISA kit; CKTSF1B2; DAND3; PRDC; cysteine knot superfamily 1; BMP antagonist 2; gremlin 2; protein related to DAN and cerberus; gremlin 2; cysteine knot superfamily; homolog (Xenopus laevis)
other names :
gremlin-2; Gremlin-2; gremlin-2; DAN domain family member 3; protein related to DAN and cerberus; cysteine knot superfamily 1, BMP antagonist 2; gremlin 2, cysteine knot superfamily, homolog; gremlin 2, DAN family BMP antagonist; Cysteine knot superfamily 1, BMP antagonist 2; DAN domain family member 3; Protein related to DAN and cerberus
products gene name :
GREM2
other gene names :
GREM2; GREM2; PRDC; DAND3; CKTSF1B2; CKTSF1B2; DAND3; PRDC
uniprot entry name :
GREM2_HUMAN
reactivity :
Human
sequence length :
168
specificity :
This assay has high sensitivity and excellent specificity for detection of human GREM2. No significant cross-reactivity or interference between human GREM2 and analogues was observed.
storage stability :
Unopened test kits should be stored at 2 to 8 degree C upon receipt. Please refer to pdf manual for further storage instructions.
other info1 :
Samples: Serum, plasma, tissue homogenates. Assay Type: Competitive. Detection Range: 6.25 pg/ml-2500 pg/ml. Sensitivity: Typically less than 6.25 pg/ml
other info2 :
Intra-assay Precision: Intra-assay Precision (Precision within an assay): CV%<15%. Three samples of known concentration were tested twenty times on one plate to assess. Inter-assay Precision: Inter-assay Precision (Precision between assays): CV%<15%. Three samples of known concentration were tested in twenty assays to assess.
products description :
Principle of the Assay: This assay employs the competitive enzyme immunoassay technique. The microtiter plate provided in this kit has been pre-coated with goat-anti-rabbit antibody. Standards or samples are added to the appropriate microtiter plate wells with an antibody specific for GREM2 and Horseradish Peroxidase (HRP) conjugated GREM2. The competitive inhibition reaction is launched between with HRP labeled GREM2 and unlabeled GREM2 with the antibody. A substrate solution is added to the wells and the color develops in opposite to the amount of GREM2 in the sample. The color development is stopped and the intensity of the color is measured.
ncbi gi num :
71164892
ncbi acc num :
NP_071914.3
ncbi gb acc num :
NM_022469.3
uniprot acc num :
Q9H772
ncbi mol weight :
19,320 Da
ncbi pathways :
Signal Transduction Pathway (477114); Signaling By BMP Pathway (106336)
ncbi summary :
This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. [provided by RefSeq, Jul 2008]
uniprot summary :
GREM2: Cytokine that inhibits the activity of BMP2 and BMP4 in a dose-dependent manner. Antagonized BMP4-induced suppression of progesterone production in granulosa cells. Belongs to the DAN family. Protein type: Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 1q43. Cellular Component: extracellular space; extracellular region. Molecular Function: heparin binding; protein homodimerization activity; cytokine activity. Biological Process: BMP signaling pathway; embryonic body morphogenesis; cytokine and chemokine mediated signaling pathway; determination of dorsal identity
size1 :
48-Strip-Wells
price1 :
510 USD
size2 :
96-Strip-Wells
price2 :
725
size3 :
5x96-Strip-Wells
price3 :
2565
size4 :
10x96-Strip-Wells
price4 :
4800
more info or order :
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.
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