Human Hepatitis A virus cellular receptor 2, HAVCR2 ELISA Kit | MyBioSource MBS946465 product information

product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Human Hepatitis A virus cellular receptor 2, HAVCR2 ELISA Kit

catalog :

MBS946465

quantity :

48-Strip-Wells

price :

510 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS946465

products type :

ELISA Kit

products full name :

Human Hepatitis A virus cellular receptor 2, HAVCR2 ELISA Kit

products short name :

hepatitis A virus cellular receptor 2

products name syn :

Human Hepatitis A virus cellular receptor 2 (HAVCR2) ELISA kit; FLJ14428; KIM-3; TIM3; TIMD3; Tim-3; T cell immunoglobulin mucin 3; T cell immunoglobulin mucin-3; kidney injury molecule-3; hepatitis A virus cellular receptor 2

other names :

hepatitis A virus cellular receptor 2; Hepatitis A virus cellular receptor 2; hepatitis A virus cellular receptor 2; kidney injury molecule-3; T-cell membrane protein 3; T cell immunoglobulin mucin 3; T cell immunoglobulin mucin-3; T-cell immunoglobulin mucin receptor 3; T-cell immunoglobulin mucin family member 3; T-cell immunoglobulin and mucin domain-containing protein 3; hepatitis A virus cellular receptor 2; T-cell immunoglobulin and mucin domain-containing protein 3; TIMD-3; T-cell immunoglobulin mucin receptor 3; TIM-3; T-cell membrane protein 3

products gene name :

HAVCR2

other gene names :

HAVCR2; HAVCR2; TIM3; KIM-3; TIMD3; Tim-3; TIMD-3; HAVcr-2; TIM3; TIMD3; HAVcr-2; TIMD-3; TIM-3

uniprot entry name :

HAVR2_HUMAN

reactivity :

Human

sequence length :

301

specificity :

This assay has high sensitivity and excellent specificity for detection of human HAVCR2. No significant cross-reactivity or interference between human HAVCR2 and analogues was observed.

storage stability :

Unopened test kits should be stored at 2 to 8 degree C upon receipt. Please refer to pdf manual for further storage instructions.

other info1 :

Samples: Serum, plasma, tissue homogenates. Assay Type: Sandwich. Detection Range: 47 pg/ml -3000 pg/ml. Sensitivity: The minimum detectable dose of human HAVCR2 is typically less than 11.75 pg/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations.

other info2 :

Intra-assay Precision: Intra-assay Precision (Precision within an assay): CV%<8%. Three samples of known concentration were tested twenty times on one plate to assess. Inter-assay Precision: Inter-assay Precision (Precision between assays): CV%<10%. Three samples of known concentration were tested in twenty assays to assess.

products description :

Principle of the assay: This assay employs the quantitative sandwich enzyme immunoassay technique. Antibody specific for HAVCR2 has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and any HAVCR2 present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for HAVCR2 is added to the wells. After washing, avidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of HAVCR2 bound in the initial step. The color development is stopped and the intensity of the color is measured.

ncbi gi num :

49574534

ncbi acc num :

NP_116171.3

ncbi gb acc num :

NM_032782.4

uniprot acc num :

Q8TDQ0

ncbi mol weight :

33,394 Da

ncbi summary :

The protein encoded by this gene belongs to the immunoglobulin superfamily, and TIM family of proteins. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas, Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. This protein is a Th1-specific cell surface protein that regulates macrophage activation, and inhibits Th1-mediated auto- and alloimmune responses, and promotes immunological tolerance. [provided by RefSeq, Sep 2011]

uniprot summary :

TIM-3: Regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. May be also involved in T-cell homing. Receptor for LGALS9. Belongs to the immunoglobulin superfamily. TIM family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral; Receptor, misc. Chromosomal Location of Human Ortholog: 5q33.3. Cellular Component: integral to membrane. Disease: Rheumatoid Arthritis

size1 :

48-Strip-Wells

price1 :

510 USD

size2 :

96-Strip-Wells

price2 :

725

size3 :

5x96-Strip-Wells

price3 :

2565

size4 :

10x96-Strip-Wells

price4 :

4800

more info or order :

MyBioSource product webpage