catalog number :
MBS9429113
products full name :
ANXA2 (Phospho-Tyr24) Antibody
products short name :
[ANXA2]
products name syn :
[Annexin A2; Annexin II; Annexin II, heavy chain; Annexin-2; ANX 2; ANX2; ANX2L4; ANXA2; ANXA2_HUMAN; arylsulfatase B; CAL1H; Calpactin I heavy chain; calpactin I heavy polypeptide (p36); Calpactin I heavy polypeptide; Calpactin-1 heavy chain; chromobindin 8; Chromobindin-8; Epididymis secretory protein Li 270; HEL S 270; LIP2; Lipocortin II; LPC2; LPC2D; p36; P36 protein; PAP-IV; Placental anticoagulant protein IV; Protein I;]
other names :
[annexin A2 isoform 2; Annexin A2; annexin A2; annexin A2; Annexin II; Annexin-2; Calpactin I heavy chain; Calpactin-1 heavy chain; Chromobindin-8; Lipocortin II; Placental anticoagulant protein IV; PAP-IV; Protein I; p36]
products gene name :
[ANXA2]
other gene names :
[ANXA2; ANXA2; P36; ANX2; LIP2; LPC2; CAL1H; LPC2D; ANX2L4; PAP-IV; HEL-S-270; ANX2; ANX2L4; CAL1H; LPC2D; PAP-IV]
reactivity :
Human, Mouse, Rat
specificity :
Phospho-ANXA2 (Phospho-Tyr24) Antibody detects endogenous levels of ANXA2 only when phosphorylated at Tyr24
purity :
The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
form :
Rabbit IgG In phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
storage stability :
Store at -20°C. Stable for 12 months from date of receipt.
tested application :
Western Blot (WB)
image1 heading :
Western Blot (WB)
other info1 :
Immunogen Description: A synthesized peptide derived from human ANXA2 around the phosphorylation site of Tyr24. Immunogen Type: Peptide
products categories :
Phospho-specific Ab
ncbi acc num :
NP_001002857.1
ncbi gb acc num :
NM_001002857.1
ncbi mol weight :
Calculated MW: 37
ncbi pathways :
Dissolution Of Fibrin Clot Pathway (1269372); Hemostasis Pathway (1269340); Immune System Pathway (1269170); Innate Immune System Pathway (1269203); Muscle Contraction Pathway (1269868); Neutrophil Degranulation Pathway (1457780); Prostaglandin Synthesis And Regulation Pathway (198912); Smooth Muscle Contraction Pathway (1269870)
ncbi summary :
This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions as an autocrine factor which heightens osteoclast formation and bone resorption. This gene has three pseudogenes located on chromosomes 4, 9 and 10, respectively. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
uniprot summary :
Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9 (PubMed:18799458, PubMed:24808179, PubMed:22848640).