product summary
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company name :
MyBioSource
product type :
antibody
product name :
PINK1 (Phospho-Ser228) Antibody
catalog :
MBS9429098
quantity :
0.05 mL
price :
200 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
western blot
more info or order :
image
image 1 :
Western blot analysis of Phospho-PINK1(Ser228) in lysates of Jurkat?, using Phospho-PINK1(Ser228) Antibody(12946).
product information
catalog number :
MBS9429098
products type :
Antibody
products full name :
PINK1 (Phospho-Ser228) Antibody
products short name :
[PINK1]
products name syn :
[BRPK; FLJ27236; mitochondrial; PARK 6; PARK6; Phosphatase and Tensin Homolog; PINK 1; PINK1; PINK1_HUMAN; Protein kinase BRPK; PTEN induced putative kinase 1; PTEN induced putative kinase protein 1; PTEN-induced putative kinase protein 1; Serine/threonine kinase PINK1 mitochondrial; Serine/threonine protein kinase PINK1 mitochondrial; Serine/threonine-protein kinase PINK1;]
other names :
[serine/threonine-protein kinase PINK1, mitochondrial; Serine/threonine-protein kinase PINK1, mitochondrial; serine/threonine-protein kinase PINK1, mitochondrial; PTEN induced putative kinase 1; BRPK; PTEN-induced putative kinase protein 1]
products gene name :
[PINK1]
other gene names :
[PINK1; PINK1; BRPK; PARK6]
clonality :
Polyclonal
isotype :
IgG
host :
Rabbit
reactivity :
Human, Mouse, Rat
sequence length :
581
specificity :
Phospho-PINK1(Phospho-Ser228) Antibody detects endogenous levels of PINK1 only when phosphorylated at Ser228
purity :
The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
form :
In phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
concentration :
1.0mg/mL
storage stability :
Store at -20 degree C. Stable for 12 months.
tested application :
Western Blot (WB)
app notes :
WB: 1:500-1:2000
image1 heading :
Western Blot (WB)
other info1 :
Immunogen: A synthesized peptide derived from human PINK1 around the phosphorylation site of Ser228. Immunogen Type: Peptide
products categories :
Phospho-specific Ab
ncbi gi num :
14165272
ncbi acc num :
NP_115785.1
ncbi gb acc num :
NM_032409.2
uniprot acc num :
Q9BXM7
ncbi mol weight :
66
ncbi pathways :
Mitophagy Pathway (1309218); Mitophagy - Animal Pathway (1496831); Mitophagy - Animal Pathway (1496741); Parkinson's Disease Pathway (83098); Parkinsons Disease Pathway (705377); Pink/Parkin Mediated Mitophagy Pathway (1309219)
ncbi summary :
This gene encodes a serine/threonine protein kinase that localizes to mitochondria. It is thought to protect cells from stress-induced mitochondrial dysfunction. Mutations in this gene cause one form of autosomal recessive early-onset Parkinson disease. [provided by RefSeq, Jul 2008]
uniprot summary :
Protects against mitochondrial dysfunction during cellular stress by phosphorylating mitochondrial proteins. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy) by mediating activation and translocation of PRKN (PubMed:14607334, PubMed:15087508, PubMed:19229105, PubMed:19966284, PubMed:20404107, PubMed:20798600, PubMed:23620051, PubMed:23754282, PubMed:23933751, PubMed:24660806, PubMed:24751536, PubMed:24784582, PubMed:24896179, PubMed:25527291). Targets PRKN to dysfunctional depolarized mitochondria through the phosphorylation of MFN2 (PubMed:23620051). Activates PRKN in 2 steps: (1) by mediating phosphorylation at 'Ser-65' of PRKN and (2) mediating phosphorylation of ubiquitin, converting PRKN to its fully-active form (PubMed:24660806, PubMed:24751536, PubMed:24784582, PubMed:25527291). Required for ubiquinone reduction by mitochondrial complex I by mediating phosphorylation of complex I subunit NDUFA10 ().
size1 :
0.05 mL
price1 :
200 USD
size2 :
0.1 mL
price2 :
255
more info or order :
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.
"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."
Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...
"MyBioSource offers the best products at unbeatable prices."
Please spend a few minutes to browse our online catalogs and see the wide range of products available. We ship our products through our shipping/distribution facility in San Diego, California, USA.
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