ELISA/assay

Human Baculoviral IAP repeat-containing protein 2 ELISA Kit

MBS9426546

96 Tests

575 USD

ELISA Kit

Human Baculoviral IAP repeat-containing protein 2 ELISA Kit

[Baculoviral IAP repeat-containing protein 2]

[Baculoviral IAP repeat-containing protein 2; C-IAP1; IAP homolog B; Inhibitor of apoptosis protein 2; IAP-2; hIAP-2; hIAP2; RING finger protein 48; TNFR2-TRAF-signaling complex protein 2]

[baculoviral IAP repeat-containing protein 2 isoform 1; Baculoviral IAP repeat-containing protein 2; baculoviral IAP repeat-containing protein 2; baculoviral IAP repeat containing 2; Cellular inhibitor of apoptosis 1; C-IAP1]

[BIRC2]

[BIRC2; BIRC2; API1; MIHB; HIAP2; RNF48; cIAP1; Hiap-2; c-IAP1; API1; MIHB; RNF48; hIAP-2; hIAP2]

Human

This assay recognizes recombinant and natural human BIRC2. No significant cross-reactivity or interference was observed.

Store at 4 degree C

Typical Testing Data/Standard Curve (for reference only)

Samples: serum, Plasma, tissue homogenates and Cell culture supernates and Other biological fluids. Detection Range: 78.0 pg/mL -5000 pg/mL

Intended Uses: This immunoassay kit allows for the in vitro quantitative determination of human baculoviral iap repeat-containing protein 2,BIRC2 concentrations in serum, Plasma, tissue homogenates and Cell culture supernates and Other biological fluids.

4502141

NP_001157.1

NM_001166.4

Q13490

64,098 Da

Activated TLR4 Signalling Pathway (106400); Apoptosis Pathway (198797); Apoptosis Pathway (83060); Apoptosis Pathway (470); Apoptosis Pathway (105648); Apoptosis Modulation And Signaling Pathway (198822); Apoptotic Cleavage Of Cellular Proteins Pathway (105678); Apoptotic Execution Phase Pathway (105677); CD40/CD40L Signaling Pathway (138061); Canonical NF-kappaB Pathway (138030)

The protein encoded by this gene is a member of a family of proteins that inhibits apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. This encoded protein inhibits apoptosis induced by serum deprivation and menadione, a potent inducer of free radicals. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

cIAP1: Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling, and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin- protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin- protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, TRAF2, DIABLO/SMAC, MAP3K14/NIK, MAP3K5/ASK1, IKBKG/NEMO and MXD1/MAD1. Can also function as an E3 ubiquitin- protein ligase of the NEDD8 conjugation pathway, targeting effector caspases for neddylation and inactivation. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8. Can stimulate the transcriptional activity of E2F1. Plays a role in the modulation of the cell cycle. Interacts with DIABLO/SMAC and with PRSS25; these interactions inhibit apoptotic suppressor activity. Interacts with CASP9. Interacts (via BIR domains) with TRAF2. Interacts with E2F1, RIPK1, RIPK2, RIPK3, RIPK4, BIRC5/survivin and USP19. Present in many fetal and adult tissues. Mainly expressed in adult skeletal muscle, thymus, testis, ovary, and pancreas, low or absent in brain and peripheral blood leukocytes. The CARD domain inhibits the activation of E3 ubiquitin ligase activity by preventing RING domain dimerization and E2 ubiquitin donor binding and activation. The CARD domain- mediated autoinhibition of the E3 ubiquitin-protein ligase activity suppresses cell proliferation and migration. USP19 regulates the stability of BIRC2/c-IAP1 by preventing its ubiquitination. Belongs to the IAP family. Protein type: EC 6.3.2.-; Ligase; Ubiquitin conjugating system; Ubiquitin ligase. Chromosomal Location of Human Ortholog: 11q22.2. Cellular Component: cytoplasm; cytosol; internal side of plasma membrane; nucleus. Molecular Function: caspase inhibitor activity; chaperone binding; protein binding; protein N-terminus binding; transcription coactivator activity; transferase activity; ubiquitin binding; ubiquitin-protein ligase activity; zinc ion binding. Biological Process: cell surface receptor linked signal transduction; I-kappaB kinase/NF-kappaB cascade; negative regulation of apoptosis; positive regulation of I-kappaB kinase/NF-kappaB cascade; proteasomal ubiquitin-dependent protein catabolic process; protein deubiquitination; protein polyubiquitination; regulation of apoptosis; regulation of cell cycle; regulation of cell differentiation; regulation of cell proliferation; regulation of inflammatory response; regulation of innate immune response; regulation of toll-like receptor signaling pathway; tumor necrosis factor-mediated signaling pathway

96 Tests

575 USD