Human muscarinic acetylcholine receptor M2, mAChRM2 autoantibody ELISA Kit | MyBioSource MBS942266 product information

product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Human muscarinic acetylcholine receptor M2, mAChRM2 autoantibody ELISA Kit

catalog :

MBS942266

quantity :

48-Strip-Wells

price :

510 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS942266

products type :

ELISA Kit

products full name :

Human muscarinic acetylcholine receptor M2, mAChRM2 autoantibody ELISA Kit

products short name :

muscarinic acetylcholine receptor M2 (mAChRM2) autoantibody

products name syn :

Human muscarinic acetylcholine receptor M2 (mAChRM2) autoantibody ELISA kit; muscarinic acetylcholine receptor M2 (mAChRM2) autoantibody

other names :

muscarinic acetylcholine receptor M2; Muscarinic acetylcholine receptor M2; muscarinic acetylcholine receptor M2; 7TM receptor; muscarinic M2 receptor; acetylcholine receptor, muscarinic 2; cholinergic receptor, muscarinic 2, isoform a; cholinergic receptor, muscarinic 2

products gene name :

mAChRM2

other gene names :

CHRM2; CHRM2; HM2

uniprot entry name :

ACM2_HUMAN

reactivity :

Human

sequence length :

466

storage stability :

Unopened test kits should be stored at 2 to 8 degree C upon receipt. Please refer to pdf manual for further storage instructions.

other info1 :

Samples: Serum

other info2 :

Detection Wavelength: 450nm. Sample Volume: 50-100ul

products description :

Principle of the Assay: This assay employs the qualitative enzyme immunoassay technique. The microtiter plate provided in this kit has been pre-coated with antigen. Samples are pipetted into the wells with anti-human immunoglobulin conjugated Horseradish Peroxidase (HRP) . Any antibodies specific for the antigen present will bind to the pre-coated antigen. Following a wash to remove any unbound reagent, a substrate solution is added to the wells and color develops in proportion to the amount of human muscarinic acetylcholine receptor M2 (mAChRM2) autoantibody bound in the initial step. The color development is stopped and the intensity of the color is measured.

ncbi gi num :

54792117

ncbi acc num :

NP_001006633.1

ncbi gb acc num :

NM_001006632.1

uniprot acc num :

P08172

ncbi mol weight :

51,715 Da

ncbi pathways :

Amine Ligand-binding Receptors Pathway (106363); Arf6 Trafficking Events Pathway (137954); Calcium Regulation In The Cardiac Cell Pathway (198906); Calcium Signaling Pathway (83050); Calcium Signaling Pathway (459); Cholinergic Synapse Pathway (217716); Class A/1 (Rhodopsin-like Receptors) Pathway (106357); G Alpha (i) Signalling Events Pathway (119550); GPCR Downstream Signaling Pathway (119548); GPCR Ligand Binding Pathway (161020)

ncbi summary :

The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine to these receptors and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 2 is involved in mediation of bradycardia and a decrease in cardiac contractility. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jul 2008]

uniprot summary :

mAChR M2: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition. Genetic variations in CHRM2 can influence susceptibility to major depressive disorder (MDD). MDD is one of the most common psychiatric disorders. MDD is a complex trait characterized by one or more major depressive episodes without a history of manic, mixed, or hypomanic episodes. A major depressive episode is characterized by at least 2 weeks during which there is a new onset or clear worsening of either depressed mood or loss of interest or pleasure in nearly all activities. Four additional symptoms must also be present including changes in appetite, weight, sleep, and psychomotor activity; decreased energy; feelings of worthlessness or guilt; difficulty thinking, concentrating, or making decisions; or recurrent thoughts of death or suicidal ideation, plans, or attempts. The episode must be accompanied by distress or impairment in social, occupational, or other important areas of functioning. Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM2 sub-subfamily. Protein type: Membrane protein, integral; GPCR, family 1; Membrane protein, multi-pass; Receptor, GPCR. Chromosomal Location of Human Ortholog: 7q31-q35. Cellular Component: postsynaptic membrane; integral to plasma membrane; plasma membrane; cell junction. Molecular Function: G-protein coupled acetylcholine receptor activity. Biological Process: G-protein signaling, coupled to cAMP nucleotide second messenger; G-protein coupled receptor protein signaling pathway; nervous system development; G-protein signaling, coupled to cyclic nucleotide second messenger; elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); acetylcholine receptor signaling, muscarinic pathway; response to virus; muscarinic acetylcholine receptor, phospholipase C activating pathway; regulation of heart contraction

size1 :

48-Strip-Wells

price1 :

510 USD

size2 :

96-Strip-Wells

price2 :

725

size3 :

5x96-Strip-Wells

price3 :

2565

size4 :

10x96-Strip-Wells

price4 :

4800

more info or order :

MyBioSource product webpage