Recombinant Rat Microtubule-associated protein tau | MyBioSource MBS9422386 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Rat Microtubule-associated protein tau

catalog :

MBS9422386

quantity :

0.01 mg

price :

230 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS9422386

products type :

Recombinant Protein

products full name :

Recombinant Rat Microtubule-associated protein tau

products short name :

[Microtubule-associated protein tau]

products name syn :

[Neurofibrillary tangle protein; Paired helical filament-tau; PHF-tau]

other names :

[Microtubule-associated protein tau; Microtubule-associated protein tau; microtubule-associated protein tau; microtubule-associated protein tau; Neurofibrillary tangle protein; Paired helical filament-tau; PHF-tau]

products gene name :

[TAU]

other gene names :

[Mapt; Mapt; Tau; pTau; Mtapt; RNPTAU; Mtapt; Tau; PHF-tau]

host :

Yeast

reactivity :

Rat

sequence positions :

[Full Length, 2-752aa]

sequence :

AEPRQEFDTMEDQAGDYTMLQDQEGDMDHGLKESPPQPP
ADDGSEEPGSETSDAKSTPTAEDVTAPLVEERAPDKQAT
AQSHTEIPEGTTAEEAGIGDTPNMEDQAAGHVTQEPQKV
EIFSQSLLVEPGRREGQAPDSGISDWTHQQVPSMSGAPL
PPQGLREATHQPLGTRPEDVERSHPASELLWQESPQKEA
WGKDRLGSEEEVDEDITMDESSQESPPSQASLAPGTATP
QARSVSASGVSGETTSIPGFPAEGSIPLPADFFSKVSAE
TQASPPEGPGTGPSEEGHEAAPEFTFHVEIKASAPKEQD
LEGATVVGAPAEEQKARGPSVGKGTKEASLLEPTDKQPA
AGLPGRPVSRVPQLKARVAGVSKDRTGNDEKKAKTSTPS
CAKTPSNRPCLSPTRPTPGSSDPLIKPSSPAVCPEPATS
PKYVSSVTPRNGSPGTKQMKLKGADGKTGAKIATPRGAA
TPGQKGTSNATRIPAKTTPSPKTPPGSGEPPKSGERSGY
SSPGSPGTPGSRSRTPSLPTPPTREPKKVAVVRTPPKSP
SASKSRLQTAPVPMPDLKNVRSKIGSTENLKHQPGGGKV
QIINKKLDLSNVQSKCGSKDNIKHVPGGGSVHIVYKPVD
LSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSK
IGSLDNITHVPGGGNKKIETHKLTFRENAKAKTDHGAEI
VYKSPVVSGDTSPRHLSNVSSTGSIDMVDSPQLATLADE
VSASLAKQGL

purity :

Greater than 90% as determined by SDS-PAGE.

form :

20mM Tris-HCl based buffer, pH8.0

storage stability :

Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

other info2 :

Tag Info: His-tag

products description :

Promotes microtubule assbly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma mbrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.

ncbi gi num :

13432197

ncbi acc num :

P19332.3

uniprot acc num :

P19332

ncbi mol weight :

80.4kD

ncbi pathways :

Alzheimer's Disease Pathway (83489); Alzheimer's Disease Pathway (509); Apoptosis Pathway (1121747); Apoptotic Cleavage Of Cellular Proteins Pathway (1121770); Apoptotic Execution Phase Pathway (1121769); Caspase-mediated Cleavage Of Cytoskeletal Proteins Pathway (1121771); MAPK Signaling Pathway (198496); MAPK Signaling Pathway (83440); MAPK Signaling Pathway (456); Programmed Cell Death Pathway (1121740)

ncbi summary :

a microtubule-associated protein; expression is found specifically in neurons [RGD, Feb 2006]

uniprot summary :

Tau: a microtubule-associated protein that regulates microtubule assembly and stability. Apparently involved in the establishment and maintenance of neuronal polarity. Mutations can result in several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. Nine differentially spliced isoforms have been described. The short isoforms allow plasticity of the cytoskeleton, whereas the longer isoforms may preferentially play a role in its stabilization. Protein type: Cytoskeletal. Chromosomal Location of Human Ortholog: 10q32.1. Cellular Component: axolemma; axon; axoneme; cell soma; cytoplasm; cytosol; dendrite; growth cone; internal side of plasma membrane; membrane; microtubule; microtubule associated complex; microtubule cytoskeleton; neuron projection; nuclear speck; nucleus; plasma membrane; postsynaptic density; tubulin complex. Molecular Function: apolipoprotein binding; DNA binding; enzyme binding; Hsp90 protein binding; identical protein binding; microtubule binding; protein binding; protein complex binding; protein domain specific binding; protein homodimerization activity; protein kinase binding; protein phosphatase 2A binding; receptor agonist activity; SH3 domain binding. Biological Process: adult walking behavior; apoptosis; axon cargo transport; axon extension; axonogenesis; brain development; female pregnancy; induction of apoptosis by oxidative stress; intracellular distribution of mitochondria; memory; microtubule cytoskeleton organization and biogenesis; mitochondrion transport along microtubule; negative regulation of intracellular transport; negative regulation of kinase activity; neurite development; neuron migration; positive regulation of axon extension; positive regulation of microtubule polymerization; positive regulation of superoxide release; regulation of autophagy; regulation of calcium-mediated signaling; regulation of microtubule polymerization or depolymerization; response to nutrient; response to organic substance; synapse organization and biogenesis

size1 :

0.01 mg

price1 :

230 USD

size2 :

0.05 mg

price2 :

290

size3 :

0.1 mg

price3 :

455

size4 :

0.2 mg

price4 :

705

size5 :

0.5 mg

price5 :

1145

size6 :

1 mg

price6 :

1800

more info or order :

MyBioSource product webpage