catalog number :
MBS9421946
products type :
Recombinant Protein
products full name :
Recombinant Human Myeloblastin
products short name :
[Myeloblastin]
products name syn :
[AGP7C-ANCA antigen; Leukocyte proteinase 3; PR-3; PR3Neutrophil proteinase 4; NP-4P29Wegener autoantigen]
other names :
[myeloblastin; Myeloblastin; myeloblastin; proteinase 3; AGP7; C-ANCA antigen; Leukocyte proteinase 3; PR-3; PR3; Neutrophil proteinase 4; NP-4; P29; Wegener autoantigen]
products gene name :
[PRTN3]
other gene names :
[PRTN3; PRTN3; MBN; MBT; NP4; P29; PR3; ACPA; AGP7; NP-4; PR-3; CANCA; C-ANCA; MBN; PR-3; PR3; NP-4]
sequence positions :
[Full Length, 28-248aa]
sequence :
YMASLQMRGN PGSHFCGGTL IHPSFVLTAA HCLRDIPQRL VNVVLGAHNV RTQEPTQQHF SVAQVFLNNYDAENKLNDVL LIQLSSPANL SASVATVQLP QQDQPVPHGT QCLAMGWGRV GAHDPPAQVLQELNVTVVTF FCRPHNICTF VPRRKAGICF GDSGGP
form :
Tris-based buffer,50% glycerol
storage stability :
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stabilityof the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life oflyophilized form is 12 months at -20°C/-80°C. Note: Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
other info1 :
Organism: Homo sapiens (Human). Tag Info: N-terminal His-tagged
products description :
Polymorphonuclear leukocyte serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro) and causes physa when administered by tracheal insufflation to hamsters.
ncbi acc num :
NP_002768.3
ncbi gb acc num :
NM_002777.3
ncbi pathways :
C-MYB Transcription Factor Network Pathway (138073)
uniprot summary :
PRTN3: Polymorphonuclear leukocyte serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro) and causes emphysema when administered by tracheal insufflation to hamsters. Belongs to the peptidase S1 family. Elastase subfamily. Protein type: Cell cycle regulation; EC 3.4.21.76; Protease. Chromosomal Location of Human Ortholog: 19p13.3. Cellular Component: cytosol; extracellular matrix; extracellular region; extracellular space; plasma membrane. Molecular Function: enzyme binding; serine-type endopeptidase activity; serine-type peptidase activity. Biological Process: antimicrobial humoral response; blood coagulation; negative regulation of phagocytosis; neutrophil degranulation; positive regulation of cell proliferation