catalog number :
MBS9421064
products type :
Recombinant Protein
products full name :
Recombinant Human papillomavirus type 16 Regulatory protein E2
products short name :
[papillomavirus type 16 Regulatory protein E2]
other names :
[regulatory protein E2; Regulatory protein E2; regulatory protein E2]
products gene name :
[VE2]
other gene names :
[E2; E2]
sequence positions :
[Full Length, 1-365aa]
sequence :
LQLTLETIYNSQYSNEKWTLQDVSLEVYLTAPTGCIKKHGYTVEVQFDGDICNTMHYTNWTHIYICEEASVTVV
EGQVDYYGLYYVHEGIRTYFVQFKDDAEKYSKNKVWEVHAGGQVILCPTSVFSSNEVSSPEIIRQHLANHPAA
THTKAVALGTEETQTTIQRPRSEPDTGNPCHTTKLLHRDSVDSAPILTAFNSSHKGRINCNSNTTPIVHLKGD
NTLKCLRYRFKKHCTLYTAVSSTWHWTGHNVKHKSAIVTLTYDSEWQRDQFLSQVKIPKTITVSTGFMSI
METLCQRLNVCQDKILTHYENDSTDLRDHIDYWKHMRLE
CAIYYKAREMGFKHINHQVVPTLAVSKNKALQAIE
purity :
Greater than 90% as determined by SDS-PAGE.
form :
20mM Tris-HCl based buffer, pH8.0
storage stability :
Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
other info2 :
Target Name: VE2. Target Species: HPV16. Calculated MW: 69.2 kD . Tag Info: GST-tag
products description :
Plays an accessory role in initiation of DNA replication. A dimer of E2 interacts with a dimer of E1 in order to improve specificity of E1 DNA binding activity. Once the complex recognizes and binds DNA at specific sites, the E2 dimer is roved from DNA. E2 also regulates viral transcription through binding to the E2RE response elent (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory regions of the viral genome. Activates or represses transcription depending on E2RE's position with regards to proximal promoter elents including the TATA-box. Repression occurs by sterically hindering the assbly of the transcription initiation complex.
ncbi acc num :
NP_041328.1
ncbi gb acc num :
NC_001526.4
uniprot summary :
Plays a role in the initiation of viral DNA replication. A dimer of E2 interacts with a dimer of E1 in order to improve specificity of E1 DNA binding activity. Once the complex recognizes and binds DNA at specific sites, the E2 dimer is removed from DNA. E2 also regulates viral transcription through binding to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory regions of the viral genome. Activates or represses transcription depending on E2RE's position with regards to proximal promoter elements including the TATA-box. Repression occurs by sterically hindering the assembly of the transcription initiation complex.