catalog number :
MBS9420926
products type :
Recombinant Protein
products full name :
Recombinant mouse Murinoglobulin-1
products short name :
[Murinoglobulin-1]
other names :
[murinoglobulin-1; Murinoglobulin-1; murinoglobulin-1; murinoglobulin 1]
products gene name :
[MUG1]
other gene names :
[Mug1; Mug1; Mug-1; MuG1]
sequence positions :
[Partial, 700-910aa]
sequence :
LSNDTGLGLSSVVPLQAFKPFFVEVSLPYSVVRGEAFMLKATVMNYLPTSMQMSVQLEASPDFTAVPVGDDQ
DSYCLSANGRHTSSWLVTPKSLGNVNFSVSAEAQQSSEPCGSEVATVPETGRKDTVVKVLIVEPE
TPEISWSLRTTLSKRPEEPPRKDPSSNDPLTETIRKYFP
ETWVWDIVTVNSTGLAEVEMTVPDTITEWKAGALC
purity :
Greater than 90% as determined by SDS-PAGE.
form :
20mM Tris-HCl based buffer, pH8.0
storage stability :
Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
other info1 :
Brief Description: Recombinant Protein
other info2 :
Tag Info: His-tag
products description :
A proteinase activates the inhibitor by specific proteolysis in the bait region, which, by an unknown mechanism leads to reaction at the cysteinyl-glutamyl internal thiol ester site and to a conformational change, whereby the proteinase is trapped and/or covalently bound to the inhibitor. While in the tetrameric proteinase inhibitors steric inhibition is sufficiently strong, monomeric forms need a covalent linkage between the activated glutamyl residue of the original thiol ester and a terminal amino group of a lysine or another nucleophilic group on the proteinase, for inhibition to be effective.
ncbi acc num :
NP_032671.2
ncbi gb acc num :
NM_008645.3
ncbi mol weight :
27.13kD
uniprot summary :
Mug1: A proteinase activates the inhibitor by specific proteolysis in the bait region, which, by an unknown mechanism leads to reaction at the cysteinyl-glutamyl internal thiol ester site and to a conformational change, whereby the proteinase is trapped and/or covalently bound to the inhibitor. While in the tetrameric proteinase inhibitors steric inhibition is sufficiently strong, monomeric forms need a covalent linkage between the activated glutamyl residue of the original thiol ester and a terminal amino group of a lysine or another nucleophilic group on the proteinase, for inhibition to be effective. Belongs to the protease inhibitor I39 (alpha-2- macroglobulin) family. Chromosomal Location of Human Ortholog: 6 6 F1. Biological Process: embryo implantation