protein

Recombinant Human Matrix metalloproteinase-14

MBS9420461

0.01 mg

180 USD

Recombinant Protein

Recombinant Human Matrix metalloproteinase-14

[Matrix metalloproteinase-14]

[MMP-X1Membrane-type matrix metalloproteinase 1; MT-MMP 1; MTMMP1Membrane-type-1 matrix metalloproteinase; MT1-MMP; MT1MMP]

[matrix metalloproteinase-14 preproprotein; Matrix metalloproteinase-14; matrix metalloproteinase-14; matrix metallopeptidase 14; MMP-X1; Membrane-type matrix metalloproteinase 1; MT-MMP 1; MTMMP1; Membrane-type-1 matrix metalloproteinase; MT1-MMP; MT1MMP]

[MMP14]

[MMP14; MMP14; MMP-14; MMP-X1; MT-MMP; MT1MMP; MTMMP1; WNCHRS; MT1-MMP; MT-MMP 1; MMP-14; MT-MMP 1; MTMMP1; MT1-MMP; MT1MMP]

E Coli

[Full Length, 112-582aa]

GDSTPFDGEGGFLAHAYFPGPNIGGDTHFDSAEPWTVRNEDLNGNDIFLVAVHELGHALGLEHSSDPSAIMA PFYQWMDTENFVLPDDDRRGIQQLYGGESGFPTKMPPQPRTTSRPSVPDKPKNPTYGPNICDGNFDTVAML RGEMFVFKERWFWRVRNNQVMDGYPMPIGQFWRGLPASINTAYERKDGKFVFFKGDKHWVFDEASLEPGY PKHIKELGRGLPTDKIDAALFWMPNGKTYFFRGNKYYRFNEELRAVDSEYPKNIKVWEGIPESPRGSFMGSDE VFTYFYKGNKYWKFNNQKLKVEPGYPKSALRDWMGCPSGGRPDEGTEEETEVIIIEVDEEGGGAVSAAAVVL PVLLLLLVLAVGLAVFFFRRHGTPRRLLYCQRSLLDKV
YAIQGLKWQHNEITFCIQNYTPKVGEYATYEAIRKAFRV
WESATPLRFREVPYAYIREGHEKQADIMIFFAEGFH

Greater than 90% as determined by SDS-PAGE.

20mM Tris-HCl based buffer, pH8.0

Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Target Name: MMP14. Target Species: Human. Calculated MW: 69.8 kD. Tag Info: His-SUMO-tag

Ses to specifically activate progelatinase A. May thus trigger invasion by tumor cells by activating progelatinase A on the tumor cell surface. May be involved in actin cytoskeleton reorganization by cleaving PTK7. Acts as a positive regulator of cell growth and migration via activation of MMP15. Involved in the formation of the fibrovascular tissues in association with pro-MMP2.

4826834

NP_004986.1

NM_004995.3

P50281

AGE/RAGE Pathway (698754); Activation Of Matrix Metalloproteinases Pathway (576264); Degradation Of Collagen Pathway (730309); Degradation Of Collagen Pathway (762258); Degradation Of The Extracellular Matrix Pathway (576263); Degradation Of The Extracellular Matrix Pathway (762256); Extracellular Matrix Organization Pathway (576262); Extracellular Matrix Organization Pathway (762247); GnRH Signaling Pathway (83091); GnRH Signaling Pathway (502)

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 protein, and this activity may be involved in tumor invasion. [provided by RefSeq, Jul 2008]

Seems to specifically activate progelatinase A. May thus trigger invasion by tumor cells by activating progelatinase A on the tumor cell surface. May be involved in actin cytoskeleton reorganization by cleaving PTK7. Acts as a positive regulator of cell growth and migration via activation of MMP15. Involved in the formation of the fibrovascular tissues in association with pro-MMP2.

0.01 mg

180 USD

0.05 mg

225

0.1 mg

320

0.2 mg

500

0.5 mg

800

1 mg

1235