Human anthrax toxin receptor 1, ANTXR1 ELISA Kit | MyBioSource MBS941904 product information

product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Human anthrax toxin receptor 1, ANTXR1 ELISA Kit

catalog :

MBS941904

quantity :

48-Strip-Wells

price :

510 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS941904

products type :

ELISA Kit

products full name :

Human anthrax toxin receptor 1, ANTXR1 ELISA Kit

products short name :

anthrax toxin receptor 1

products name syn :

Human anthrax toxin receptor 1 (ANTXR1) ELISA kit; ATR; FLJ10601; FLJ11298; FLJ21776; TEM8; 2310008J16Rik; 2810405N18Rik; tumor endothelial marker 8; anthrax toxin receptor 1

other names :

anthrax toxin receptor 1 isoform 3; Anthrax toxin receptor 1; anthrax toxin receptor 1; 2310008J16Rik; 2810405N18Rik; tumor endothelial marker 8; anthrax toxin receptor 1; Tumor endothelial marker 8

products gene name :

ANTXR1

other gene names :

ANTXR1; ANTXR1; ATR; GAPO; TEM8; ATR; TEM8

uniprot entry name :

ANTR1_HUMAN

reactivity :

Human

sequence length :

333

specificity :

This assay has high sensitivity and excellent specificity for detection of human ANTXR1. No significant cross-reactivity or interference between human ANTXR1 and analogues was observed.

storage stability :

Unopened test kits should be stored at 2 to 8 degree C upon receipt. Please refer to pdf manual for further storage instructions.

other info1 :

Samples: Serum, plasma, tissue homogenates. Assay Type: Sandwich. Detection Range: 62. 5 pg/ml -4000 pg/ml. Sensitivity: The minimum detectable dose of human ANTXR1 is typically less than 15.6 pg/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations.

other info2 :

Intra-assay Precision: Intra-assay Precision (Precision within an assay): CV%<8%. Three samples of known concentration were tested twenty times on one plate to assess. Inter-assay Precision: Inter-assay Precision (Precision between assays): CV%<10%. Three samples of known concentration were tested in twenty assays to assess.

products description :

Principle of the assay: This assay employs the quantitative sandwich enzyme immunoassay technique. Antibody specific for ANTXR1 has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and any ANTXR1 present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for ANTXR1 is added to the wells. After washing, avidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of ANTXR1 bound in the initial step. The color development is stopped and the intensity of the color is measured.

ncbi gi num :

16933553

ncbi acc num :

NP_060623.2

ncbi gb acc num :

NM_018153.3

uniprot acc num :

Q9H6X2

ncbi mol weight :

62,789 Da

ncbi pathways :

Cellular Roles Of Anthrax Toxin Pathway (138076)

ncbi summary :

This gene encodes a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. The encoded protein has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disrupt normal cellular processes. Three alternatively spliced variants that encode different protein isoforms have been described. [provided by RefSeq, Oct 2008]

uniprot summary :

ANTXR1: Plays a role in cell attachment and migration. Interacts with extracellular matrix proteins and with the actin cytoskeleton. Mediates adhesion of cells to type 1 collagen and gelatin, reorganization of the actin cytoskeleton and promotes cell spreading. Plays a role in the angiogenic response of cultured umbilical vein endothelial cells. Defects in ANTXR1 are associated with susceptibility to hemangioma capillary infantile (HCI). HCI are benign, highly proliferative lesions involving aberrant localized growth of capillary endothelium. They are the most common tumor of infancy, occurring in up to 10% of all births. Hemangiomas tend to appear shortly after birth and show rapid neonatal growth for up to 12 months characterized by endothelial hypercellularity and increased numbers of mast cells. This phase is followed by slow involution at a rate of about 10% per year and replacement by fibrofatty stroma. Belongs to the ATR family. 4 isoforms of the human protein are produced by alternative splicing. Protein type: Receptor, misc.; Actin-binding; Membrane protein, integral. Chromosomal Location of Human Ortholog: 2p13.1. Cellular Component: filopodium membrane; cell surface; plasma membrane; integral to membrane; endosome membrane. Molecular Function: collagen binding; actin filament binding; protein binding; transmembrane receptor activity; metal ion binding. Biological Process: actin cytoskeleton reorganization; reproductive process; pathogenesis; signal transduction. Disease: Gapo Syndrome; Hemangioma, Capillary Infantile

size1 :

48-Strip-Wells

price1 :

510 USD

size2 :

96-Strip-Wells

price2 :

725

size3 :

5x96-Strip-Wells

price3 :

2565

size4 :

10x96-Strip-Wells

price4 :

4800

more info or order :

MyBioSource product webpage