product summary
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company name :
MyBioSource
product type :
antibody
product name :
Na+ CP type II alpha Antibody
catalog :
MBS9418759
quantity :
0.05 mL
price :
200 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
western blot
more info or order :
image
image 1 :
Western blot analysis Na+ CP type II alpha using Jurkat whole cell lysates
product information
catalog number :
MBS9418759
products type :
Antibody
products full name :
Na+ CP type II alpha Antibody
products short name :
[Na+ CP type II alpha]
products name syn :
[SCN2A; Brain sodium channel type II; BFIC3; BFNIS; EIEE11; HBSC II; HBSCI; Na(v)1.2; NachII; SCN2A2; ScpII; BFIS3; HBA; HBSCII; NAC2; Nav1.2; RNSCPIIR; SCN2A1]
other names :
[sodium channel protein type 2 subunit alpha isoform 1; Sodium channel protein type 2 subunit alpha; sodium channel protein type 2 subunit alpha; sodium voltage-gated channel alpha subunit 2; HBSC II; Sodium channel protein brain II subunit alpha; Sodium channel protein type II subunit alpha; Voltage-gated sodium channel subunit alpha Nav1.2]
products gene name :
[Na+ CP type II alpha]
other gene names :
[SCN2A; SCN2A; HBA; NAC2; BFIC3; BFIS3; BFNIS; HBSCI; EIEE11; HBSCII; Nav1.2; SCN2A1; SCN2A2; Na(v)1.2; NAC2; SCN2A1; SCN2A2]
uniprot entry name :
SCN2A_HUMAN
clonality :
Polyclonal
host :
Rabbit
reactivity :
Human, Mouse, Rat
sequence length :
2005
specificity :
Na+ CP type II alpha Antibody detects endogenous levels of total Na+ CP type II alpha
purity :
Immunogen affinity purified
form :
Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
concentration :
1.0mg/mL
storage stability :
Store at -20 degree C
tested application :
Western Blot (WB)
app notes :
Western Blot: 1:1000-3000
image1 heading :
Western Blot (WB)
other info1 :
Immunogen: A synthesized peptide derived from human Na+ CP type II alpha. Immunogen Type: Peptide
other info2 :
Calculated MW: 227 kDa
products categories :
Total protein Ab
ncbi gi num :
93141212
ncbi acc num :
NP_001035232.1
ncbi gb acc num :
NM_001040142.1
uniprot acc num :
Q99250
ncbi pathways :
Axon Guidance Pathway (1270303); Cardiac Conduction Pathway (1339115); Developmental Biology Pathway (1270302); Interaction Between L1 And Ankyrins Pathway (1270325); L1CAM Interactions Pathway (1270323); Muscle Contraction Pathway (1269868); Phase 0 - Rapid Depolarisation Pathway (1339117); Taste Transduction Pathway (83088); Taste Transduction Pathway (499)
ncbi summary :
Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with four repeat domains, each of which is composed of six membrane-spanning segments, and one or more regulatory beta subunits. Voltage-gated sodium channels function in the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel alpha subunit gene family. Allelic variants of this gene are associated with seizure disorders and autism spectrum disorder. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2016]
uniprot summary :
SCN2A: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. Defects in SCN2A are the cause of seizures, benign familial infantile type 3 (BFIS3). An autosomal dominant disorder in which afebrile seizures occur in clusters during the first year of life, without neurologic sequelae. Defects in SCN2A are the cause of epileptic encephalopathy early infantile type 11 (EIEE11). EIEE11 is an autosomal dominant seizure disorder characterized by infantile onset of refractory seizures with resultant delayed neurologic development and persistent neurologic abnormalities. Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.2/SCN2A subfamily. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass. Chromosomal Location of Human Ortholog: 2q24.3. Cellular Component: axon; integral to plasma membrane; intrinsic to plasma membrane. Molecular Function: voltage-gated sodium channel activity. Biological Process: generation of action potential; myelination; sodium ion transport. Disease: Epileptic Encephalopathy, Early Infantile, 11; Seizures, Benign Familial Infantile, 3
size1 :
0.05 mL
price1 :
200 USD
size2 :
0.1 mL
price2 :
255
more info or order :
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.
"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."
Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...
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