product summary
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company name :
MyBioSource
product type :
ELISA/assay
product name :
Rat Kynurenine 3-monooxygenase, KMO ELISA Kit
catalog :
MBS941871
quantity :
48-Strip-Wells
price :
510 USD
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS941871
products type :
ELISA Kit
products full name :
Rat Kynurenine 3-monooxygenase, KMO ELISA Kit
products short name :
kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
products name syn :
Rat Kynurenine 3-monooxygenase (KMO) ELISA kit; RP1-317G22.1; dJ317G22.1; kynurenine 3-hydroxylase; kynurenine 3-monooxygenase; kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
other names :
kynurenine 3-monooxygenase; Kynurenine 3-monooxygenase; kynurenine 3-monooxygenase; kynurenine 3-hydroxylase; kynurenine 3-monooxygenase (kynurenine 3-hydroxylase); Kynurenine 3-hydroxylase
products gene name :
KMO
other gene names :
Kmo; Kmo
uniprot entry name :
KMO_RAT
reactivity :
Rat
sequence length :
478
specificity :
This assay has high sensitivity and excellent specificity for detection of rat KMO. No significant cross-reactivity or interference between rat KMO and analogues was observed.
storage stability :
Unopened test kits should be stored at 2 to 8 degree C upon receipt. Please refer to pdf manual for further storage instructions.
other info1 :
Samples: Serum, plasma, tissue homogenates, cell lysates. Assay Type: Quantitative Sandwich. Sensitivity: Typically less than 3.9 pg/ml.
other info2 :
Intra-assay Precision: Intra-assay Precision (Precision within an assay): CV%<8%. Three samples of known concentration were tested twenty times on one plate to assess. Inter-assay Precision: Inter-assay Precision (Precision between assays): CV%<10%. Three samples of known concentration were tested in twenty assays to assess.
products description :
Principle of the Assay: This assay employs the quantitative sandwich enzyme immunoassay technique. Antibody specific for KMO has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and any KMO present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for KMO is added to the wells. After washing, avidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of KMO bound in the initial step. The color development is stopped and the intensity of the color is measured.
ncbi gi num :
11024672
ncbi acc num :
NP_067604.1
ncbi gb acc num :
NM_021593.1
uniprot acc num :
O88867
ncbi mol weight :
54,353 Da
ncbi pathways :
Folic Acid Network Pathway (219799); Metabolism Pathway (573935); Metabolism Of Amino Acids And Derivatives Pathway (574057); Tryptophan Catabolism Pathway (574064); Tryptophan Metabolism Pathway (83356); Tryptophan Metabolism Pathway (332); Selenium Pathway (219762)
ncbi summary :
human homolog is an NADPH-dependent flavin monooxygenase that catalyzes the hydroxylation of L-kynurenine to form L-3-hydroxykynurenine [RGD, Feb 2006]
uniprot summary :
KMO: Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract. Belongs to the aromatic-ring hydroxylase family. KMO subfamily. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, multi-pass; Mitochondrial; Membrane protein, integral; Oxidoreductase; Amino Acid Metabolism - tryptophan; EC 1.14.13.9. Cellular Component: mitochondrial outer membrane; mitochondrion; mitochondrial inner membrane; integral to membrane. Molecular Function: FAD binding; NAD(P)H oxidase activity; kynurenine 3-monooxygenase activity. Biological Process: anthranilate metabolic process; tryptophan catabolic process to kynurenine; NAD metabolic process; quinolinate biosynthetic process; response to salt stress
size1 :
48-Strip-Wells
price1 :
510 USD
size2 :
96-Strip-Wells
price2 :
725
size3 :
5x96-Strip-Wells
price3 :
2565
size4 :
10x96-Strip-Wells
price4 :
4800
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
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