catalog number :
MBS941815
products type :
ELISA Kit
products full name :
Human Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1, LINGO1 ELISA Kit
products short name :
leucine rich repeat and Ig domain containing 1
products name syn :
Human Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 (LINGO1) ELISA kit; FLJ14594; LERN1; LRRN6A; MGC17422; UNQ201; leucine rich repeat neuronal 6A; leucine-rich repeat neuronal 6A; leucine-rich repeat neuronal protein 1; leucine rich repeat and Ig domain containing 1
other names :
leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform a; Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1; leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1; leucine rich repeat neuronal 6A; leucine-rich repeat neuronal protein 1; leucine-rich repeat and immunoglobulin domain-containing protein 1; leucine rich repeat and Ig domain containing 1; Leucine-rich repeat and immunoglobulin domain-containing protein 1; Leucine-rich repeat neuronal protein 1; Leucine-rich repeat neuronal protein 6A
products gene name :
LINGO1
other gene names :
LINGO1; LINGO1; LERN1; LRRN6A; UNQ201; LERN1; LRRN6A; UNQ201/PRO227
uniprot entry name :
LIGO1_HUMAN
specificity :
This assay has high sensitivity and excellent specificity for detection of Human LINGO1. No significant cross-reactivity or interference between Human LINGO1 and analogues was observed.
storage stability :
Unopened test kits should be stored at 2 to 8 degree C upon receipt. Please refer to pdf manual for further storage instructions.
other info2 :
Intra-assay Precision: Intra-assay Precision (Precision within an assay): CV% is less than 8%. Three samples of known concentration were tested twenty times on one plate to assess. Inter-assay Precision (Precision between assays): CV% is less than 10%. Three samples of known concentration were tested in twenty assays to assess. Detection Wavelength: 450 nm. Sample Volume: 50-100ul
ncbi acc num :
NP_116197.4
ncbi gb acc num :
NM_032808.6
ncbi mol weight :
69,876 Da
ncbi pathways :
Axonal Growth Inhibition (RHOA Activation) Pathway (106454); Signal Transduction Pathway (477114); Signalling By NGF Pathway (106439); P75 NTR Receptor-mediated Signalling Pathway (106441); P75NTR Regulates Axonogenesis Pathway (106452)
uniprot summary :
LINGO1: Functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors. Is also an important negative regulator of oligodentrocyte differentiation and axonal myelination. Acts in conjunction with RTN4 and RTN4R in regulating neuronal precursor cell motility during cortical development. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral. Chromosomal Location of Human Ortholog: 15q24.3. Cellular Component: plasma membrane; integral to membrane. Molecular Function: epidermal growth factor receptor binding. Biological Process: negative regulation of oligodendrocyte differentiation; nerve growth factor receptor signaling pathway; protein kinase B signaling cascade; negative regulation of axonogenesis; regulation of axonogenesis; neurite development; central nervous system neuron development
size4 :
10x96-Strip-Wells