BMP4 Antibody | MyBioSource MBS9417271 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

BMP4 Antibody

catalog :

MBS9417271

quantity :

0.1 mL

price :

255 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry

more info or order :

MyBioSource product webpage

image

image 1 :

Gel: 8%SDS-PAGE Lysate: 40 ug, Lane: Hela cell lysate, Primary antibody:BMP4 antibody at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute

image 2 :

The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using BMP4 Antibody at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: x200)

product information

catalog number :

MBS9417271

products type :

Antibody

products full name :

BMP4 Antibody

products short name :

[BMP4]

products name syn :

[ZYME; BMP2B; OFC11; BMP2B1; MCOPS6]

other names :

[bone morphogenetic protein 4 isoform a preproprotein; Bone morphogenetic protein 4; bone morphogenetic protein 4; bone morphogenetic protein 4; Bone morphogenetic protein 2B; BMP-2B]

products gene name :

[BMP4]

other gene names :

[BMP4; BMP4; ZYME; BMP2B; OFC11; BMP2B1; MCOPS6; BMP2B; DVR4; BMP-4; BMP-2B]

uniprot entry name :

BMP4_HUMAN

clonality :

Polyclonal

host :

Rabbit

reactivity :

Human, Mouse, Rat

sequence length :

408

specificity :

The antibody detects endogenous levels of total BMP4 protein.

purity :

Antigen affinity purification

form :

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

concentration :

0.5mg/ml

storage stability :

Store at -20 degree C

tested application :

Immunohistochemistry (IHC), Western Blot (WB)

app notes :

Western Blot: 1:200-1000. Immunohistochemistry: 1: 20-100

image1 heading :

SDS-Page

image2 heading :

Immunohistochemistry (IHC)

other info1 :

Immunogen: Synthetic peptide of human BMP4. Immunogen Type: Peptide

products categories :

Total protein Ab

products description :

This gene encodes a member of the bone morphogenetic protein (BMP) family of proteins, which is part of the transforming growth factor-beta (TGF-beta) superfamily. Members of the BMP family play an important role in bone and cartilage development. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. Mutations in this gene are associated with orofacial cleft and microphthalmia in human patients. The encoded protein may also be involved in the pathology of multiple cardiovascular diseases and human cancers. Alternative splicing results in multiple transcript variants.

ncbi gi num :

157276593

ncbi acc num :

NP_001193.2

ncbi gb acc num :

NM_001202.5

uniprot acc num :

P12644

ncbi mol weight :

47kd

ncbi pathways :

Adipogenesis Pathway (198832); BMP Signaling Pathway (1084755); BMP Signaling Pathway (1108218); Basal Cell Carcinoma Pathway (83113); Basal Cell Carcinoma Pathway (525); Cardiac Progenitor Differentiation Pathway (712094); Differentiation Pathway (1458184); Differentiation Of White And Brown Adipocyte Pathway (1458280); Ectoderm Differentiation Pathway (1458276); Elastic Fibre Formation Pathway (1270251)

ncbi summary :

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates heart development and adipogenesis. Mutations in this gene are associated with orofacial cleft and microphthalmia in human patients. The encoded protein may also be involved in the pathology of multiple cardiovascular diseases and human cancers. [provided by RefSeq, Jul 2016]

uniprot summary :

BMP4: Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction. Homodimer; disulfide-linked. Interacts with GREM2. Part of a complex consisting of TWSG1 and CHRD. Interacts with the serine proteases, HTRA1 and HTRA3; the interaction with either inhibits BMP4-mediated signaling. The HTRA protease activity is required for this inhibition. Interacts with SOSTDC1. Expressed in the lung and lower levels seen in the kidney. Present also in normal and neoplastic prostate tissues, and prostate cancer cell lines. Belongs to the TGF-beta family. Protein type: Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 14q22-q23. Cellular Component: extracellular region; extracellular space. Molecular Function: chemoattractant activity; cytokine activity; protein binding; transforming growth factor beta receptor binding. Biological Process: activation of MAPKK activity; alveolus development; blood vessel endothelial cell proliferation during sprouting angiogenesis; BMP signaling pathway; branching morphogenesis of a tube; chondrocyte differentiation; common-partner SMAD protein phosphorylation; endochondral ossification; hemopoietic progenitor cell differentiation; intermediate mesodermal cell differentiation; kidney development; lymphoid progenitor cell differentiation; macrophage differentiation; mesonephros development; monocyte differentiation; negative regulation of apoptosis; negative regulation of cell cycle; negative regulation of cell proliferation; negative regulation of immature T cell proliferation in the thymus; negative regulation of MAP kinase activity; negative regulation of mitosis; negative regulation of myoblast differentiation; negative regulation of phosphorylation; negative regulation of striated muscle development; negative regulation of T cell differentiation in the thymus; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; odontogenesis; osteoblast differentiation; positive regulation of apoptosis; positive regulation of BMP signaling pathway; positive regulation of bone mineralization; positive regulation of cardiac muscle fiber development; positive regulation of collagen biosynthetic process; positive regulation of endothelial cell proliferation; positive regulation of epidermal cell differentiation; positive regulation of epithelial cell proliferation; positive regulation of ossification; positive regulation of osteoblast differentiation; positive regulation of protein amino acid phosphorylation; positive regulation of protein binding; positive regulation of smooth muscle cell proliferation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; post-embryonic development; regulation of cell fate commitment; regulation of protein import into nucleus; smooth muscle development; smoothened signaling pathway; steroid hormone mediated signaling; telencephalon development; ureteric bud branching; ureteric bud development. Disease: Microphthalmia, Syndromic 6; Orofacial Cleft 11

size1 :

0.1 mL

price1 :

255 USD

more info or order :

MyBioSource product webpage