antibody

CAMKK1/2 (Phospho-Ser458/495) Antibody

MBS9416580

0.05 mL

200 USD

polyclonal

rabbit

nonconjugated

human, mouse, rat

Antibody

CAMKK1/2 (Phospho-Ser458/495) Antibody

[CAMKK1/2]

[CAMKK1; CaM-kinase IV kinase; CaM-kinase kinase 1; CaM-kinase kinase alpha; CAMKK alpha protein; CAMKKA; CaM-KK 1; CaMKK; CaM-KK alpha; CaMKK 1; CaMKK alpha; CAMKKalpha]

[calcium/calmodulin-dependent protein kinase kinase 1 isoform a; Calcium/calmodulin-dependent protein kinase kinase 1; calcium/calmodulin-dependent protein kinase kinase 1; calcium/calmodulin dependent protein kinase kinase 1; CaM-kinase IV kinase; Calcium/calmodulin-dependent protein kinase kinase alpha; CaM-KK alpha; CaM-kinase kinase alpha; CaMKK alpha]

[CAMKK1/2]

[CAMKK1; CAMKK1; CAMKKA; CAMKKA; CaM-KK 1; CaM-kinase kinase 1; CaMKK 1; CaM-KK alpha; CaM-kinase kinase alpha; CaMKK alpha]

KKCC1_HUMAN

Polyclonal

Rabbit

Human, Mouse, Rat

505

CAMKK1/2 (Phospho-Ser458/495) Antibody detects endogenous levels of CAMKK1/2 only when phosphorylated at Ser458/495

Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

1 mg/ml

Store at -20°C

Western Blot (WB)

Western Blot: 1:1000

Western Blot (WB)

Immunogen: A synthesized peptide derived from human CAMKK1/2 (Phospho-Ser458/495). Immunogen Type: Peptide. Target Species: Human. Calculated MW: 64 kD

Modification: Phospho-Ser458/495

Phospho-specific Ab

14150045

NP_115670.1

NM_032294.2

Q8N5S9

AMP-activated Protein Kinase (AMPK) Signaling Pathway (198868); AMPK Signaling Pathway (989139); AMPK Signaling Pathway (992181); Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway (1268798); Adipocytokine Signaling Pathway (83093); Adipocytokine Signaling Pathway (505); Alcoholism Pathway (585563); Alcoholism Pathway (587116); CREB Phosphorylation Through The Activation Of CaMKK Pathway (1268806); Longevity Regulating Pathway (1319989)

The product of this gene belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. This protein plays a role in the calcium/calmodulin-dependent (CaM) kinase cascade. Three transcript variants encoding two distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

CAMKK1: a calcium/calmodulin-dependent S/T protein kinase of the CAMKK family. Phosphorylates CAMK1, CAMK1D, CAMK1G and CAMK4. Involved in regulating cell apoptosis. Promotes cell survival by phosphorylating AKT1/PKB that inhibits pro-apoptotic BAD/Bcl2-antagonist of cell death. 2 isoforms of the human protein are produced by alternative splicing. The autoinhibitory domain overlaps with the calmodulin binding region and may be involved in intrasteric autoinhibition. Binding of calmodulin may releave intrasteric autoinhibition. May be regulated through phosphorylation by CAMK1 and CAMK4. Appears to be autophosphorylated in a Ca2+/calmodulin-dependent manner. Phosphorylation of Ser-458 is blocked upon binding to Ca2+/calmodulin. Protein type: CAMKK family; EC 2.7.11.17; Kinase, protein; Meta subfamily; Other group; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor). Chromosomal Location of Human Ortholog: 17p13.2. Cellular Component: cytoplasm; cytosol; nucleus. Molecular Function: calmodulin binding; calmodulin-dependent protein kinase activity; protein binding. Biological Process: peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; positive regulation of protein kinase activity

0.05 mL

200 USD

0.1 mL

255